Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage
Dissotis rotundifolia is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2020/7656127 |
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| author | Michael Buenor Adinortey Charles Ansah Benjamin Aboagye Justice Kwabena Sarfo Orleans Martey Alexander Kwadwo Nyarko |
| author_facet | Michael Buenor Adinortey Charles Ansah Benjamin Aboagye Justice Kwabena Sarfo Orleans Martey Alexander Kwadwo Nyarko |
| author_sort | Michael Buenor Adinortey |
| collection | DOAJ |
| description | Dissotis rotundifolia is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable. The drive for carrying out this research was to obtain data on the possible ameliorative effect of the whole plant extract of Dissotis rotundifolia (DRE) in gastric ulcerations induced by ethanol in Sprague Dawley (SD) rats. SD rats were pretreated with 100, 300, and 500 mg/kg of DRE for 14 days after which an ulcerogen-ethanol was administered. Gross examinations of the stomach lining and histological analysis of gastric lesions were carried out coupled with an assessment of the antioxidant activity of gastric mucosa using MDA, GSH, CAT, and SOD as indicators. The data suggested a significant attenuation in gastric mucosal damage in DRE-pretreated ethanol-induced gastric ulcer reflected in the antioxidant status. There was also a reduction or absence of hemorrhage, edema, and leucocytes infiltration in DRE-treated groups compared to the negative control group. DRE conserved glutathione (GSH) levels, reduced malondialdehyde (MDA) levels, and enhanced catalase (CAT) and superoxide dismutase (SOD) enzyme levels. The present study shows that DRE possess protective effects against ethanol-induced ulcer damage in the stomach of rats, which could be attributed to its antioxidant activity. |
| format | Article |
| id | doaj-art-bbd8fa85fff24befadc11eeb3b0b5a4a |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-bbd8fa85fff24befadc11eeb3b0b5a4a2025-02-03T01:30:30ZengWileyBiochemistry Research International2090-22472090-22552020-01-01202010.1155/2020/76561277656127Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal DamageMichael Buenor Adinortey0Charles Ansah1Benjamin Aboagye2Justice Kwabena Sarfo3Orleans Martey4Alexander Kwadwo Nyarko5Department of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaCentre for Plant Medicine Research, Mampong, Akuapim, GhanaDepartment of Pharmacology, School of Pharmacy, University of Ghana, Legon, Accra, GhanaDissotis rotundifolia is a plant in the family Melastomataceae. The methanolic extract of the whole plant is reported to be rich in C-glycosylflavones such as vitexin and orientin. Though there are several reports on the ethnomedicinal use of this plant extract in stomach ulcers, experimental-based data is unavailable. The drive for carrying out this research was to obtain data on the possible ameliorative effect of the whole plant extract of Dissotis rotundifolia (DRE) in gastric ulcerations induced by ethanol in Sprague Dawley (SD) rats. SD rats were pretreated with 100, 300, and 500 mg/kg of DRE for 14 days after which an ulcerogen-ethanol was administered. Gross examinations of the stomach lining and histological analysis of gastric lesions were carried out coupled with an assessment of the antioxidant activity of gastric mucosa using MDA, GSH, CAT, and SOD as indicators. The data suggested a significant attenuation in gastric mucosal damage in DRE-pretreated ethanol-induced gastric ulcer reflected in the antioxidant status. There was also a reduction or absence of hemorrhage, edema, and leucocytes infiltration in DRE-treated groups compared to the negative control group. DRE conserved glutathione (GSH) levels, reduced malondialdehyde (MDA) levels, and enhanced catalase (CAT) and superoxide dismutase (SOD) enzyme levels. The present study shows that DRE possess protective effects against ethanol-induced ulcer damage in the stomach of rats, which could be attributed to its antioxidant activity.http://dx.doi.org/10.1155/2020/7656127 |
| spellingShingle | Michael Buenor Adinortey Charles Ansah Benjamin Aboagye Justice Kwabena Sarfo Orleans Martey Alexander Kwadwo Nyarko Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage Biochemistry Research International |
| title | Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage |
| title_full | Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage |
| title_fullStr | Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage |
| title_full_unstemmed | Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage |
| title_short | Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage |
| title_sort | flavonoid rich extract of dissotis rotundifolia whole plant protects against ethanol induced gastric mucosal damage |
| url | http://dx.doi.org/10.1155/2020/7656127 |
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