Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial

Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial

Abstract Background Postoperative cognitive dysfunction (POCD) is one of the major complications after surgery, with devastating clinical outcomes. Although POCD is a condition with a multifactorial pathophysiology, blood-brain barrier (BBB) dysfunction and neuronal injury have been shown to play a...

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Bibliographic Details
Main Authors: Wongook Wi, Hyo-Jin Kim, Sira Bang, Oh Joo Kweon, Doyeon Kim, Eun Jung Oh
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Trials
Subjects:
Blood-brain barrier
Cerebrospinal fluid
Inhaled anesthetics
Intravenous anesthetics
Neuroinflammation
Postoperative cognitive dysfunction
Online Access:https://doi.org/10.1186/s13063-024-08515-w
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https://doi.org/10.1186/s13063-024-08515-w

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