Nicotinamide mononucleotide restores impaired metabolism, endothelial cell proliferation and angiogenesis in old sedentary male mice

Summary: Aging is accompanied by a decline in neovascularization potential and increased susceptibility to ischemic injury. Here, we confirm the age-related impaired neovascularization following ischemic leg injury and impaired angiogenesis. The age-related deficits in angiogenesis arose primarily f...

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Main Authors: Kevin Kiesworo, Thomas Agius, Michael R. Macarthur, Martine Lambelet, Arnaud Lyon, Jing Zhang, Guillermo Turiel, Zheng Fan, Sènan d’Almeida, Korkut Uygun, Heidi Yeh, Sébastien Déglise, Katrien de Bock, Sarah J. Mitchell, Alejandro Ocampo, Florent Allagnat, Alban Longchamp
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
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Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224028839
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