siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration.

Host DNA repair enzymes have long been assumed to play a role in HIV replication, and many different DNA repair factors have been associated with HIV. In order to identify DNA repair pathways required for HIV infection, we conducted a targeted siRNA screen using 232 siRNA pools for genes associated...

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Bibliographic Details
Main Authors: Amy S Espeseth, Rick Fishel, Daria Hazuda, Qian Huang, Min Xu, Kristine Yoder, Honglin Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0017612&type=printable
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