Association between serum testosterone changes and parameters of the metabolic syndrome
Testosterone production is important in males, and various physical and psychological abnormalities occur in individuals with low testosterone levels. In the present study, we aimed to examine the effects of longitudinal changes in total testosterone levels in the same cohort. We included 178 male s...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-12-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0106/_html/-char/en |
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| author | Sohei Kuribayashi Shinichiro Fukuhara Hiroaki Kitakaze Go Tsujimura Takahiro Imanaka Norichika Ueda Kentaro Takezawa Hiroshi Kiuchi Ayaka Tachi Jiro Sakamoto Toyofumi Abe Go Tanigawa Yasushi Miyagawa Takashi Fujimoto Norio Nonomura |
| author_facet | Sohei Kuribayashi Shinichiro Fukuhara Hiroaki Kitakaze Go Tsujimura Takahiro Imanaka Norichika Ueda Kentaro Takezawa Hiroshi Kiuchi Ayaka Tachi Jiro Sakamoto Toyofumi Abe Go Tanigawa Yasushi Miyagawa Takashi Fujimoto Norio Nonomura |
| author_sort | Sohei Kuribayashi |
| collection | DOAJ |
| description | Testosterone production is important in males, and various physical and psychological abnormalities occur in individuals with low testosterone levels. In the present study, we aimed to examine the effects of longitudinal changes in total testosterone levels in the same cohort. We included 178 male subjects who visited our hospital multiple times between 2018 and 2023 for medical checkups for at least 3 years. The median baseline age and total testosterone level (TT) of the cohort were 61 years and 4.74 ng/mL, respectively. The patients were divided into four groups based on the difference in TT (ΔTT) between baseline and last visit (Q1, n = 45; Q2, n = 45; Q3, n = 44; Q4, n = 44). ΔTT values ranged from –3.07 to –0.78 ng/mL in Q1, from –0.75 to –0.05 ng/mL in Q2, from –0.03 to 0.73 ng/mL in Q3, and from 0.75 ng/mL to 3.4 ng/mL in Q4. The median ΔTT were –1.22 for Q1, –0.35 for Q2, +0.19 for Q3, and +1.43 for Q4. Decreased TT tended to increase body weight, body mass index, waist circumference, and visceral fat (p for trend 0.0136, 0.0272, 0.0354, and 0.0032, respectively), and decrease adiponectin level (p for trend 0.0219). Herein, we found that decreased TT increases visceral fat and decreases adiponectin levels. |
| format | Article |
| id | doaj-art-bb1e79103d2b4cf8ad73b41e65ac34b3 |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-bb1e79103d2b4cf8ad73b41e65ac34b32025-01-22T05:34:07ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-12-0171121125113310.1507/endocrj.EJ24-0106endocrjAssociation between serum testosterone changes and parameters of the metabolic syndromeSohei Kuribayashi0Shinichiro Fukuhara1Hiroaki Kitakaze2Go Tsujimura3Takahiro Imanaka4Norichika Ueda5Kentaro Takezawa6Hiroshi Kiuchi7Ayaka Tachi8Jiro Sakamoto9Toyofumi Abe10Go Tanigawa11Yasushi Miyagawa12Takashi Fujimoto13Norio Nonomura14Department of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanDepartment of Urology, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Urology, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Urology, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Urology, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanPhysical Check-up Center, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Urology, Osaka University Graduate School of Medicine, Osaka 565-0871, JapanTestosterone production is important in males, and various physical and psychological abnormalities occur in individuals with low testosterone levels. In the present study, we aimed to examine the effects of longitudinal changes in total testosterone levels in the same cohort. We included 178 male subjects who visited our hospital multiple times between 2018 and 2023 for medical checkups for at least 3 years. The median baseline age and total testosterone level (TT) of the cohort were 61 years and 4.74 ng/mL, respectively. The patients were divided into four groups based on the difference in TT (ΔTT) between baseline and last visit (Q1, n = 45; Q2, n = 45; Q3, n = 44; Q4, n = 44). ΔTT values ranged from –3.07 to –0.78 ng/mL in Q1, from –0.75 to –0.05 ng/mL in Q2, from –0.03 to 0.73 ng/mL in Q3, and from 0.75 ng/mL to 3.4 ng/mL in Q4. The median ΔTT were –1.22 for Q1, –0.35 for Q2, +0.19 for Q3, and +1.43 for Q4. Decreased TT tended to increase body weight, body mass index, waist circumference, and visceral fat (p for trend 0.0136, 0.0272, 0.0354, and 0.0032, respectively), and decrease adiponectin level (p for trend 0.0219). Herein, we found that decreased TT increases visceral fat and decreases adiponectin levels.https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0106/_html/-char/enadiponectinlongitudinaltestosteronevisceral fat |
| spellingShingle | Sohei Kuribayashi Shinichiro Fukuhara Hiroaki Kitakaze Go Tsujimura Takahiro Imanaka Norichika Ueda Kentaro Takezawa Hiroshi Kiuchi Ayaka Tachi Jiro Sakamoto Toyofumi Abe Go Tanigawa Yasushi Miyagawa Takashi Fujimoto Norio Nonomura Association between serum testosterone changes and parameters of the metabolic syndrome Endocrine Journal adiponectin longitudinal testosterone visceral fat |
| title | Association between serum testosterone changes and parameters of the metabolic syndrome |
| title_full | Association between serum testosterone changes and parameters of the metabolic syndrome |
| title_fullStr | Association between serum testosterone changes and parameters of the metabolic syndrome |
| title_full_unstemmed | Association between serum testosterone changes and parameters of the metabolic syndrome |
| title_short | Association between serum testosterone changes and parameters of the metabolic syndrome |
| title_sort | association between serum testosterone changes and parameters of the metabolic syndrome |
| topic | adiponectin longitudinal testosterone visceral fat |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/12/71_EJ24-0106/_html/-char/en |
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