Pre-Vaccination Immune Profiles and Responsiveness to Innate Stimuli Predict Reactogenicity and Antibody Magnitude Following mRNA Vaccination

Pre-Vaccination Immune Profiles and Responsiveness to Innate Stimuli Predict Reactogenicity and Antibody Magnitude Following mRNA Vaccination

Background: While mRNA vaccines effectively limit hospitalization and severe COVID-19 disease, the precise early innate immune mechanisms associated with their efficacy and reactogenicity remain underexplored. The identification of innate immune correlates prior to vaccination could provide mechanis...

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Bibliographic Details
Main Authors: Amanda E. Zelkoski, Emilie Goguet, Emily Samuels Darcey, Mohamad-Gabriel Alameh, Hooda Said, Simon Pollett, John H. Powers, Eric D. Laing, Cara Olsen, Edward Mitre, Allison M. W. Malloy
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
mRNA vaccine
BNT162b2
antibody
dendritic cells
monocytes
reactogenicity
Online Access:https://www.mdpi.com/2076-393X/13/7/718
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