Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex
Summary: The visual cortex predicts incoming sensory stimuli through internal models that are updated following unexpected events. Cortical inhibitory neurons, particularly vasoactive intestinal polypeptide (VIP) interneurons, play a critical role in representing unexpected stimuli. Notably, this re...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224029559 |
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| author | Farzaneh Najafi Simone Russo Jérôme Lecoq |
| author_facet | Farzaneh Najafi Simone Russo Jérôme Lecoq |
| author_sort | Farzaneh Najafi |
| collection | DOAJ |
| description | Summary: The visual cortex predicts incoming sensory stimuli through internal models that are updated following unexpected events. Cortical inhibitory neurons, particularly vasoactive intestinal polypeptide (VIP) interneurons, play a critical role in representing unexpected stimuli. Notably, this response is stimulus non-specific, raising the question of what information it conveys. Given their unique connectivity, we hypothesized that during unexpected stimuli, VIP neurons encode broad context signals, referred to here as task-independent information. To test this hypothesis, we analyzed the Allen Institute Visual Behavior dataset, in which mice viewed repeated familiar images and unexpected omissions of these images, while two-photon calcium imaging was performed from distinct cell types across primary and higher-order visual areas. Using dimensionality reduction methods, we found that, in contrast to image presentations, unexpected omissions trigger task-independent signaling in VIP and excitatory neurons. This signaling may facilitate the integration of contextual and sensory information, enabling updated predictions. |
| format | Article |
| id | doaj-art-bad6963a4f0a460ea77fa14929c8bccc |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-bad6963a4f0a460ea77fa14929c8bccc2025-01-18T05:05:05ZengElsevieriScience2589-00422025-02-01282111728Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortexFarzaneh Najafi0Simone Russo1Jérôme Lecoq2Georgia Institute of Technology, Biological Sciences, Atlanta, GA, USA; Allen Institute for Brain Science, Mindscope Program, Seattle, WA, USA; Corresponding authorAllen Institute for Brain Science, Brain and Consciousness Program, Seattle, WA, USA; Georgia Institute of Technology, Wallace H Coulter Department of Biomedical Engineering, Atlanta, GA, USA; Department of Biomedical and Clinical Sciences, Università degli Studi di Milano, 20157 Milan, ItalyAllen Institute for Brain Science, Neural Dynamics Program, Seattle, WA, USA; Corresponding authorSummary: The visual cortex predicts incoming sensory stimuli through internal models that are updated following unexpected events. Cortical inhibitory neurons, particularly vasoactive intestinal polypeptide (VIP) interneurons, play a critical role in representing unexpected stimuli. Notably, this response is stimulus non-specific, raising the question of what information it conveys. Given their unique connectivity, we hypothesized that during unexpected stimuli, VIP neurons encode broad context signals, referred to here as task-independent information. To test this hypothesis, we analyzed the Allen Institute Visual Behavior dataset, in which mice viewed repeated familiar images and unexpected omissions of these images, while two-photon calcium imaging was performed from distinct cell types across primary and higher-order visual areas. Using dimensionality reduction methods, we found that, in contrast to image presentations, unexpected omissions trigger task-independent signaling in VIP and excitatory neurons. This signaling may facilitate the integration of contextual and sensory information, enabling updated predictions.http://www.sciencedirect.com/science/article/pii/S2589004224029559Natural sciencesBiological sciencesNeuroscienceSystems neuroscience |
| spellingShingle | Farzaneh Najafi Simone Russo Jérôme Lecoq Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex iScience Natural sciences Biological sciences Neuroscience Systems neuroscience |
| title | Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| title_full | Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| title_fullStr | Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| title_full_unstemmed | Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| title_short | Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex |
| title_sort | unexpected events trigger task independent signaling in vip and excitatory neurons of mouse visual cortex |
| topic | Natural sciences Biological sciences Neuroscience Systems neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224029559 |
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