Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.

Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial.

<h4>Background</h4>Major protease mutations are rarely observed following failure with protease inhibitors (PI), and other viral determinants of failure to PI are poorly understood. We therefore characterized Gag-Protease phenotypic susceptibility in subtype A and D viruses circulating i...

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Main Authors: Katherine A Sutherland, Chris M Parry, Adele McCormick, Anne Kapaata, Fred Lyagoba, Pontiano Kaleebu, Charles F Gilks, Ruth Goodall, Moira Spyer, Cissy Kityo, Deenan Pillay, Ravindra K Gupta, DART Virology Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0137834
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https://doi.org/10.1371/journal.pone.0137834

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