Circadian phase inversion causes insulin resistance in a rat model of night work and jet lag

Circadian phase inversion causes insulin resistance in a rat model of night work and jet lag

Abstract Shift workers have an increased risk to develop type 2 diabetes. We aimed to investigate the underlying mechanisms and the role of the timing of food intake by subjecting rats to an acute phase inversion of the light/dark (L/D) cycle. In the first experiment, with food available ad libitum,...

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Bibliographic Details
Main Authors: Anhui Wang, Ewout Foppen, Valentina S. Rumanova, Tess Kool, Andries Kalsbeek, Dirk J. Stenvers
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Circadian rhythm
Daily rhythms
Phase-shift
Desynchronization
Shift work
Metabolism
Online Access:https://doi.org/10.1038/s41598-025-91485-z
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https://doi.org/10.1038/s41598-025-91485-z

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