Engineered ipilimumab variants that bind human and mouse CTLA-4

Engineered ipilimumab variants that bind human and mouse CTLA-4

Testing of candidate monoclonal antibody therapeutics in preclinical models is an essential step in drug development. Identification of antibody therapeutic candidates that bind their human targets and cross-react to mouse orthologs is often challenging, especially for targets with low sequence homo...

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Bibliographic Details
Main Authors: Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean West, Pavel Strop, Peter S. Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Antibody engineering
CTLA-4
immune checkpoint
phage display
species cross reactivity
yeast display
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2451296
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2451296

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