Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice

Reverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice

The newly emerged avian influenza A H5N1 Clade 2.3.4.4b can infect dairy cows and shed live virus in their milk. Sporadic cattle-to-human infections have been reported, highlighting the urgent need to understand its pathogenesis in mammals. Using both non-lactating and lactating BALB/c mice, we exam...

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Main Authors: Na Xiao, Xiang Yong Oong, Yanxia Chen, Can Li, Howard Chun-Ho Chung, Pui Wang, Zhanhong Ye, Alvin Hiu-Chung Lam, Jianpiao Cai, Wenchen Song, Andrew Chak-Yiu Lee, Hin Chu, Kin-Hang Kok, Jasper Fuk-Woo Chan, Shuofeng Yuan, Honglin Chen, Kwok-Yung Yuen, Anna Jin-Xia Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Clade 2.3.4.4b
H5N1
cattle
BALB/c mice
mammary gland
pathogenesis
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2475836
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2475836

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