ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy

ADAR1 haploinsufficiency and sustained picornaviral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi-system interferonopathy

ABSTRACT Sensing of viral double-stranded RNA (dsRNA) by MDA5 triggers abundant but transient interferon-stimulated gene (ISGs) expression. If dsRNA synthesis is made persistent by transgenically expressing a picornaviral RNA-dependent RNA polymerase (RdRp) in mice, lifelong MDA5-MAVS pathway activa...

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Main Authors: Caitlin M. Miller, James H. Morrison, Laura Bankers, Rachael Dran, Julia M. Kendrick, Emma Briggs, Virginia L. Ferguson, Eric M. Poeschla
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
ADAR1
MDA5
innate antiviral immunity
picornavirus
RdRp
autoimmunity
Online Access:https://journals.asm.org/doi/10.1128/mbio.01492-25
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https://journals.asm.org/doi/10.1128/mbio.01492-25

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