Review of Biological Network Data and Its Applications
Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and th...
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| Format: | Article |
| Language: | English |
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BioMed Central
2013-12-01
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| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-11-200.pdf |
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| _version_ | 1832572571771469824 |
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| author | Donghyeon Yu MinSoo Kim Guanghua Xiao Tae Hyun Hwang |
| author_facet | Donghyeon Yu MinSoo Kim Guanghua Xiao Tae Hyun Hwang |
| author_sort | Donghyeon Yu |
| collection | DOAJ |
| description | Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study. |
| format | Article |
| id | doaj-art-b9eb6c96c4744eb4ba5e6cc2bbef0c5d |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-b9eb6c96c4744eb4ba5e6cc2bbef0c5d2025-02-02T09:14:44ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-12-0111420021010.5808/GI.2013.11.4.20060Review of Biological Network Data and Its ApplicationsDonghyeon Yu0MinSoo Kim1Guanghua Xiao2Tae Hyun Hwang3Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Department of Clinical Sciences, Quantitative Biomedical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.http://genominfo.org/upload/pdf/gni-11-200.pdfbiological networkdisease gene prioritizationgene regulatory networksgenome-wide association studyprotein function predictionprotein-protein interaction |
| spellingShingle | Donghyeon Yu MinSoo Kim Guanghua Xiao Tae Hyun Hwang Review of Biological Network Data and Its Applications Genomics & Informatics biological network disease gene prioritization gene regulatory networks genome-wide association study protein function prediction protein-protein interaction |
| title | Review of Biological Network Data and Its Applications |
| title_full | Review of Biological Network Data and Its Applications |
| title_fullStr | Review of Biological Network Data and Its Applications |
| title_full_unstemmed | Review of Biological Network Data and Its Applications |
| title_short | Review of Biological Network Data and Its Applications |
| title_sort | review of biological network data and its applications |
| topic | biological network disease gene prioritization gene regulatory networks genome-wide association study protein function prediction protein-protein interaction |
| url | http://genominfo.org/upload/pdf/gni-11-200.pdf |
| work_keys_str_mv | AT donghyeonyu reviewofbiologicalnetworkdataanditsapplications AT minsookim reviewofbiologicalnetworkdataanditsapplications AT guanghuaxiao reviewofbiologicalnetworkdataanditsapplications AT taehyunhwang reviewofbiologicalnetworkdataanditsapplications |