Sirtuin 1: A Dilemma in Transplantation
Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations. In view of the anti-inflammatory properties of sirtuin 1 along with its protective rol...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2020/9012980 |
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| author | Sara Assadiasl Nuala Mooney Bahareh Mohebbi Yousef Fatahi Narjes Soleimanifar |
| author_facet | Sara Assadiasl Nuala Mooney Bahareh Mohebbi Yousef Fatahi Narjes Soleimanifar |
| author_sort | Sara Assadiasl |
| collection | DOAJ |
| description | Sirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations. In view of the anti-inflammatory properties of sirtuin 1 along with its protective role in ischemia reperfusion injury, it might be considered as contributing to the promotion of transplantation outcome. However, the potential ability of sirtuin 1 to induce malignancies raises some concerns about its overexpression in clinic. Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation. The identification of sirtuin 1 natural and synthetic activators leads to the proposal of sirtuin 1 as an eligible target for clinical interventions in transplantation. All positive and negative consequences of sirtuin 1 overactivation/overexpression in the allograft should therefore be studied thoroughly. Herein, we summarize previous findings concerning direct and indirect influences of sirtuin 1 manipulation on transplantation. |
| format | Article |
| id | doaj-art-b9d7a5555dcc40eda3f07cc416a67c6d |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-b9d7a5555dcc40eda3f07cc416a67c6d2025-02-03T01:26:25ZengWileyJournal of Transplantation2090-00072090-00152020-01-01202010.1155/2020/90129809012980Sirtuin 1: A Dilemma in TransplantationSara Assadiasl0Nuala Mooney1Bahareh Mohebbi2Yousef Fatahi3Narjes Soleimanifar4Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranHuman Immunology and Immunopathology, Inserm UMR 976, Paris, FranceMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranMolecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, IranSirtuin 1, a member of sirtuin family of histone deacetylase enzymes, has been implicated in a variety of physiologic and pathologic events, including energy metabolism, cell survival, and age-related alterations. In view of the anti-inflammatory properties of sirtuin 1 along with its protective role in ischemia reperfusion injury, it might be considered as contributing to the promotion of transplantation outcome. However, the potential ability of sirtuin 1 to induce malignancies raises some concerns about its overexpression in clinic. Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation. The identification of sirtuin 1 natural and synthetic activators leads to the proposal of sirtuin 1 as an eligible target for clinical interventions in transplantation. All positive and negative consequences of sirtuin 1 overactivation/overexpression in the allograft should therefore be studied thoroughly. Herein, we summarize previous findings concerning direct and indirect influences of sirtuin 1 manipulation on transplantation.http://dx.doi.org/10.1155/2020/9012980 |
| spellingShingle | Sara Assadiasl Nuala Mooney Bahareh Mohebbi Yousef Fatahi Narjes Soleimanifar Sirtuin 1: A Dilemma in Transplantation Journal of Transplantation |
| title | Sirtuin 1: A Dilemma in Transplantation |
| title_full | Sirtuin 1: A Dilemma in Transplantation |
| title_fullStr | Sirtuin 1: A Dilemma in Transplantation |
| title_full_unstemmed | Sirtuin 1: A Dilemma in Transplantation |
| title_short | Sirtuin 1: A Dilemma in Transplantation |
| title_sort | sirtuin 1 a dilemma in transplantation |
| url | http://dx.doi.org/10.1155/2020/9012980 |
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