Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota

Bacteroides fragilis capsular polysaccharide A ameliorates ulcerative colitis in rat by recovering intestinal barrier integrity and restoring gut microbiota

Bacteroides fragilis (B. fragilis) is a Gram-negative, obligate anaerobic, commensal bacterium residing in the human gut and holds therapeutic potential for ulcerative colitis (UC). Previous studies have indicated that capsular polysaccharide A (PSA) of B. fragilis is a crucial component for its eff...

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Main Authors: Yijia Zhong, Xiujuan Chang, Zihan Zhao, Lijun Zheng, Gaobo Kuang, Ping Li, Chenxuexuan Liu, Yuqin Fan, Zhixuan Liang, Ke Zhuang, Qiuling Xie, Yangyang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
Bacteroides fragilis
capsular polysaccharide A
ulcerative colitis
intestinal barrier function
intestinal microbiota
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1402465/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1402465/full

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