Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin
Five novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with a...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/395386 |
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| author | Y. Rajendra Prasad P. Ravi Kumar Ch. Asha Deepti M. Venkata Ramana |
| author_facet | Y. Rajendra Prasad P. Ravi Kumar Ch. Asha Deepti M. Venkata Ramana |
| author_sort | Y. Rajendra Prasad |
| collection | DOAJ |
| description | Five novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds were evaluated by the cup plate method. |
| format | Article |
| id | doaj-art-b98e21035e914ccc9bb906529fbcc4a8 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-b98e21035e914ccc9bb906529fbcc4a82025-02-03T05:45:16ZengWileyE-Journal of Chemistry0973-49452090-98102006-01-013423624110.1155/2006/395386Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl CoumarinY. Rajendra Prasad0P. Ravi Kumar1Ch. Asha Deepti2M. Venkata Ramana3University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, (A.P), IndiaUniversity College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, (A.P), IndiaUniversity College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, (A.P), IndiaUniversity College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, (A.P), IndiaFive novel chalcones were synthesised by condensing 2-hydroxy-1-acetonaphthone with aldehyde derivatives in dilute ethanolic potassium hydroxide solution at room temperature according to Claisen-Schmidt condensation and another five novel chalcones were prepared by refluxing 3-acetyl coumarin with aldehydes in the presence of piperidine in ethanol. All these compounds were characterised by means of their IR, 1H NMR spectroscopic data and microanalyses. The antimicrobial activity of these compounds were evaluated by the cup plate method.http://dx.doi.org/10.1155/2006/395386 |
| spellingShingle | Y. Rajendra Prasad P. Ravi Kumar Ch. Asha Deepti M. Venkata Ramana Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin E-Journal of Chemistry |
| title | Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin |
| title_full | Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin |
| title_fullStr | Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin |
| title_full_unstemmed | Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin |
| title_short | Synthesis and Antimicrobial Activity of Some Novel Chalcones of 2-Hydroxy -1-Acetonapthone and 3-Acetyl Coumarin |
| title_sort | synthesis and antimicrobial activity of some novel chalcones of 2 hydroxy 1 acetonapthone and 3 acetyl coumarin |
| url | http://dx.doi.org/10.1155/2006/395386 |
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