Inhibition of the Renin–Angiotensin System Improves Hemodynamic Function of the Diabetic Rat Heart by Restoring Intracellular Calcium Regulation

Inhibition of the Renin–Angiotensin System Improves Hemodynamic Function of the Diabetic Rat Heart by Restoring Intracellular Calcium Regulation

<b>Background/Objectives:</b> Disrupted intracellular calcium (Ca<sup>2+</sup><sub>i</sub>) regulation and renin–angiotensin system (RAS) activation are pathogenetic factors in diabetic cardiomyopathy, a major complication of type 1 (T1D) and type 2 (T2D) diabetes...

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Main Authors: Krisztina Anna Paulik, Tamás Ivanics, Gábor A. Dunay, Ágnes Fülöp, Margit Kerék, Klára Takács, Zoltán Benyó, Zsuzsanna Miklós
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
renin–angiotensin system (RAS)
losartan
enalapril
Langendorff heart
diabetic cardiomyopathy
type 1 diabetes
Online Access:https://www.mdpi.com/2227-9059/13/3/757
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