Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases
Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses. RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3+ inducible regulatory T cel...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/3067126 |
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| author | Luana de Mendonça Oliveira Franciane Mouradian Emidio Teixeira Maria Notomi Sato |
| author_facet | Luana de Mendonça Oliveira Franciane Mouradian Emidio Teixeira Maria Notomi Sato |
| author_sort | Luana de Mendonça Oliveira |
| collection | DOAJ |
| description | Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses. RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3+ inducible regulatory T cells, and induces gut-homing specificity in T cells. Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases. The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents. Here, we review the effect of RA on innate and adaptive immunity with a special emphasis on inflammatory status. |
| format | Article |
| id | doaj-art-b981ec4a33cd4d23a152cc27d1554220 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b981ec4a33cd4d23a152cc27d15542202025-02-03T01:11:11ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/30671263067126Impact of Retinoic Acid on Immune Cells and Inflammatory DiseasesLuana de Mendonça Oliveira0Franciane Mouradian Emidio Teixeira1Maria Notomi Sato2Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, University of São Paulo, Institute of Tropical Medicine of São Paulo, São Paulo, SP, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, University of São Paulo, Institute of Tropical Medicine of São Paulo, São Paulo, SP, BrazilLaboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine, University of São Paulo, Institute of Tropical Medicine of São Paulo, São Paulo, SP, BrazilVitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation, organogenesis, and reproduction and a key role in mucosal immune responses. RA promotes dendritic cells to express CD103 and to produce RA, enhances the differentiation of Foxp3+ inducible regulatory T cells, and induces gut-homing specificity in T cells. Although vitamin A is crucial for maintaining homeostasis at the intestinal barrier and equilibrating immunity and tolerance, including gut dysbiosis, retinoids perform a wide variety of functions in many settings, such as the central nervous system, skin aging, allergic airway diseases, cancer prevention and therapy, and metabolic diseases. The mechanism of RA is interesting to explore as both a mucosal adjuvant and a combination therapy with other effective agents. Here, we review the effect of RA on innate and adaptive immunity with a special emphasis on inflammatory status.http://dx.doi.org/10.1155/2018/3067126 |
| spellingShingle | Luana de Mendonça Oliveira Franciane Mouradian Emidio Teixeira Maria Notomi Sato Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases Mediators of Inflammation |
| title | Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases |
| title_full | Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases |
| title_fullStr | Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases |
| title_full_unstemmed | Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases |
| title_short | Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases |
| title_sort | impact of retinoic acid on immune cells and inflammatory diseases |
| url | http://dx.doi.org/10.1155/2018/3067126 |
| work_keys_str_mv | AT luanademendoncaoliveira impactofretinoicacidonimmunecellsandinflammatorydiseases AT francianemouradianemidioteixeira impactofretinoicacidonimmunecellsandinflammatorydiseases AT marianotomisato impactofretinoicacidonimmunecellsandinflammatorydiseases |