The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes
Infection with Toxoplasma gondii (T. gondii) during the pregnant period and its potentially miserable outcomes for the fetus, newborn, and even adult offspring continuously occur worldwide. People acquire infection through the consumption of infected and undercooked meat or contaminated food or wate...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8782672 |
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| author | Xuyang Gao Yue Zhong Yifan Liu Runmin Ding Jinling Chen |
| author_facet | Xuyang Gao Yue Zhong Yifan Liu Runmin Ding Jinling Chen |
| author_sort | Xuyang Gao |
| collection | DOAJ |
| description | Infection with Toxoplasma gondii (T. gondii) during the pregnant period and its potentially miserable outcomes for the fetus, newborn, and even adult offspring continuously occur worldwide. People acquire infection through the consumption of infected and undercooked meat or contaminated food or water. T. gondii infection in pregnant women primarily during the gestation causes microcephaly, mental and psychomotor retardation, or death. Abnormal pregnancy outcomes are mainly associated with regulatory T cell (Treg) dysfunction. Tregs, a special subpopulation of T cells, function as a vital regulator in maintaining immune homeostasis. Tregs exert a critical effect on forming and maintaining maternal-fetal tolerance and promoting fetal development during the pregnancy period. Forkhead box P3 (Foxp3), a significant functional factor of Tregs, determines the status of Tregs. In this review, we summarize the effects of T. gondii infection on host Tregs and its critical transcriptional factor, Foxp3. |
| format | Article |
| id | doaj-art-b9647b083663444eaa6b0eddd8ca80e4 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b9647b083663444eaa6b0eddd8ca80e42025-02-03T05:43:46ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/87826728782672The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy OutcomesXuyang Gao0Yue Zhong1Yifan Liu2Runmin Ding3Jinling Chen4Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, 226001 Jiangsu, ChinaDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, 226001 Jiangsu, ChinaDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, 226001 Jiangsu, ChinaDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, 226001 Jiangsu, ChinaDepartment of Pathogen Biology, School of Medicine, Nantong University, Nantong, 226001 Jiangsu, ChinaInfection with Toxoplasma gondii (T. gondii) during the pregnant period and its potentially miserable outcomes for the fetus, newborn, and even adult offspring continuously occur worldwide. People acquire infection through the consumption of infected and undercooked meat or contaminated food or water. T. gondii infection in pregnant women primarily during the gestation causes microcephaly, mental and psychomotor retardation, or death. Abnormal pregnancy outcomes are mainly associated with regulatory T cell (Treg) dysfunction. Tregs, a special subpopulation of T cells, function as a vital regulator in maintaining immune homeostasis. Tregs exert a critical effect on forming and maintaining maternal-fetal tolerance and promoting fetal development during the pregnancy period. Forkhead box P3 (Foxp3), a significant functional factor of Tregs, determines the status of Tregs. In this review, we summarize the effects of T. gondii infection on host Tregs and its critical transcriptional factor, Foxp3.http://dx.doi.org/10.1155/2021/8782672 |
| spellingShingle | Xuyang Gao Yue Zhong Yifan Liu Runmin Ding Jinling Chen The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes Journal of Immunology Research |
| title | The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes |
| title_full | The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes |
| title_fullStr | The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes |
| title_full_unstemmed | The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes |
| title_short | The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes |
| title_sort | role and function of regulatory t cells in toxoplasma gondii induced adverse pregnancy outcomes |
| url | http://dx.doi.org/10.1155/2021/8782672 |
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