The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury
Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2012/802384 |
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| author | M. Elias-Miró M. B. Jiménez-Castro M. Mendes-Braz A. Casillas-Ramírez C. Peralta |
| author_facet | M. Elias-Miró M. B. Jiménez-Castro M. Mendes-Braz A. Casillas-Ramírez C. Peralta |
| author_sort | M. Elias-Miró |
| collection | DOAJ |
| description | Strategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects. |
| format | Article |
| id | doaj-art-b9365665d0b1465f8cedc2b539032ca3 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-b9365665d0b1465f8cedc2b539032ca32025-02-03T05:53:32ZengWileyPPAR Research1687-47571687-47652012-01-01201210.1155/2012/802384802384The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion InjuryM. Elias-Miró0M. B. Jiménez-Castro1M. Mendes-Braz2A. Casillas-Ramírez3C. Peralta4Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Roselló 149–153, 3rd Floor, Office 3.8, 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Roselló 149–153, 3rd Floor, Office 3.8, 08036 Barcelona, SpainDepartamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade de Sao Paulo, 14049-900 Sao Paulo, SP, BrazilInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Roselló 149–153, 3rd Floor, Office 3.8, 08036 Barcelona, SpainInstitut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Esther Koplowitz Center, Roselló 149–153, 3rd Floor, Office 3.8, 08036 Barcelona, SpainStrategies to improve the viability of steatotic livers could reduce the risk of dysfunction after surgery and increase the number of organs suitable for transplantation. Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. Potential therapies based on PPAR regulation will be discussed. The data suggest that further investigations are required to elucidate whether PPAR could be a potential therapeutic target in liver surgery and to determine the most effective therapies that selectively regulate PPAR with minor side effects.http://dx.doi.org/10.1155/2012/802384 |
| spellingShingle | M. Elias-Miró M. B. Jiménez-Castro M. Mendes-Braz A. Casillas-Ramírez C. Peralta The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury PPAR Research |
| title | The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury |
| title_full | The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury |
| title_fullStr | The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury |
| title_full_unstemmed | The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury |
| title_short | The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury |
| title_sort | current knowledge of the role of ppar in hepatic ischemia reperfusion injury |
| url | http://dx.doi.org/10.1155/2012/802384 |
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