Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects
Disrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases....
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/8191079 |
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| _version_ | 1832566157638369280 |
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| author | Xiao-yan Zhou Rong Gao Jian Hu Da-peng Gao Yan-ling Liao Jian-jun Yang |
| author_facet | Xiao-yan Zhou Rong Gao Jian Hu Da-peng Gao Yan-ling Liao Jian-jun Yang |
| author_sort | Xiao-yan Zhou |
| collection | DOAJ |
| description | Disrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases. However, it remains unclear whether immune memory can cause subsequent alterations in the brain immune response and affect neurobehavioral outcomes in sepsis survivors. In the present study, mice received daily intraperitoneal injection of low-dose lipopolysaccharide (LPS, 0.1 mg/kg) for three consecutive days to induce immune memory (immune tolerance) and then were subjected to sham operation or cecal ligation and puncture (CLP) 9 months later, followed by a battery of neurobehavioral and biochemical studies. Here, we showed that repeated low-dose LPS injection-induced immune memory protected mice from sepsis-induced cognitive and affective impairments, which were accompanied by significantly decreased brain proinflammatory cytokines and immune response. In conclusion, our study suggests that modulation of brain immune responses by repeated LPS injections confers neuroprotective effects by preventing overactivated immune response in response to subsequent septic insult. |
| format | Article |
| id | doaj-art-b8dfb7f2d2e945e8b1639372420f245b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b8dfb7f2d2e945e8b1639372420f245b2025-02-03T01:05:02ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/81910798191079Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective EffectsXiao-yan Zhou0Rong Gao1Jian Hu2Da-peng Gao3Yan-ling Liao4Jian-jun Yang5Department of Anesthesiology, Jinling Hospital, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Emergency and Intensive Care Medicine, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Nanjing Lishui People’s Hospital, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Jinling Hospital, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Jinling Hospital, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Anesthesiology, Jinling Hospital, Jinling Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu, ChinaDisrupted immune response is an important feature of many neurodegenerative conditions, including sepsis-associated cognitive impairment. Accumulating evidence has demonstrated that immune memory occurs in microglia, which has a significant impact on pathological hallmarks of neurological diseases. However, it remains unclear whether immune memory can cause subsequent alterations in the brain immune response and affect neurobehavioral outcomes in sepsis survivors. In the present study, mice received daily intraperitoneal injection of low-dose lipopolysaccharide (LPS, 0.1 mg/kg) for three consecutive days to induce immune memory (immune tolerance) and then were subjected to sham operation or cecal ligation and puncture (CLP) 9 months later, followed by a battery of neurobehavioral and biochemical studies. Here, we showed that repeated low-dose LPS injection-induced immune memory protected mice from sepsis-induced cognitive and affective impairments, which were accompanied by significantly decreased brain proinflammatory cytokines and immune response. In conclusion, our study suggests that modulation of brain immune responses by repeated LPS injections confers neuroprotective effects by preventing overactivated immune response in response to subsequent septic insult.http://dx.doi.org/10.1155/2020/8191079 |
| spellingShingle | Xiao-yan Zhou Rong Gao Jian Hu Da-peng Gao Yan-ling Liao Jian-jun Yang Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects Mediators of Inflammation |
| title | Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects |
| title_full | Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects |
| title_fullStr | Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects |
| title_full_unstemmed | Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects |
| title_short | Trained Innate Immunity by Repeated Low-Dose Lipopolysaccharide Injections Displays Long-Term Neuroprotective Effects |
| title_sort | trained innate immunity by repeated low dose lipopolysaccharide injections displays long term neuroprotective effects |
| url | http://dx.doi.org/10.1155/2020/8191079 |
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