Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients
The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral h...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2018/1691474 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564219600437248 |
|---|---|
| author | Christian Akem Dimala Benjamin Momo Kadia Ben-Lawrence Kemah Maxime Tindong Simeon-Pierre Choukem |
| author_facet | Christian Akem Dimala Benjamin Momo Kadia Ben-Lawrence Kemah Maxime Tindong Simeon-Pierre Choukem |
| author_sort | Christian Akem Dimala |
| collection | DOAJ |
| description | The aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon was conducted. Linear and logistic regression models were used as appropriate to explore the association between the variables of interest. Results. There was no linear association between log CD4 count and both systolic (p=0.200; r=0.12) and diastolic blood pressures (p=0.123; r=0.14), respectively. After adjusting for BMI, patients with CD4 count ≥ 350 cells/μl were more likely to have hypertension than those with CD4 count < 350 cells/μl (AOR: 2.50, 95% CI: 1.05–5.93, and p=0.032). There was no effect modification from BMI (test of homogeneity, p=0.721). There was no independent relationship between CD4 count and hypertension after controlling for age, sex, family history of hypertension, BMI-defined overweight, HAART use, and duration of HIV infection (AOR: 1.66, 95% CI: 0.48–5.71, and p=0.419). Conclusion. This study did not identify any independent relationship between CD4 count and hypertension. Large prospective studies are recommended to better explore this relationship between hypertension and CD4 count. |
| format | Article |
| id | doaj-art-b8d2348c64ca43728d7ca403d8cdb176 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-b8d2348c64ca43728d7ca403d8cdb1762025-02-03T01:11:38ZengWileyInternational Journal of Hypertension2090-03842090-03922018-01-01201810.1155/2018/16914741691474Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected PatientsChristian Akem Dimala0Benjamin Momo Kadia1Ben-Lawrence Kemah2Maxime Tindong3Simeon-Pierre Choukem4Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UKPresbyterian General Hospital Acha-Tugi, Acha-Tugi, CameroonHealth and Human Development (2HD) Research Network, Douala, CameroonHealth and Human Development (2HD) Research Network, Douala, CameroonHealth and Human Development (2HD) Research Network, Douala, CameroonThe aim of this study was to establish whether an independent relationship exists between CD4 count and hypertension and if this relationship is modified or confounded by the body mass index (BMI). Methods. A secondary data analysis of a cross-sectional study on 200 HIV/AIDS patients at a referral hospital in Cameroon was conducted. Linear and logistic regression models were used as appropriate to explore the association between the variables of interest. Results. There was no linear association between log CD4 count and both systolic (p=0.200; r=0.12) and diastolic blood pressures (p=0.123; r=0.14), respectively. After adjusting for BMI, patients with CD4 count ≥ 350 cells/μl were more likely to have hypertension than those with CD4 count < 350 cells/μl (AOR: 2.50, 95% CI: 1.05–5.93, and p=0.032). There was no effect modification from BMI (test of homogeneity, p=0.721). There was no independent relationship between CD4 count and hypertension after controlling for age, sex, family history of hypertension, BMI-defined overweight, HAART use, and duration of HIV infection (AOR: 1.66, 95% CI: 0.48–5.71, and p=0.419). Conclusion. This study did not identify any independent relationship between CD4 count and hypertension. Large prospective studies are recommended to better explore this relationship between hypertension and CD4 count.http://dx.doi.org/10.1155/2018/1691474 |
| spellingShingle | Christian Akem Dimala Benjamin Momo Kadia Ben-Lawrence Kemah Maxime Tindong Simeon-Pierre Choukem Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients International Journal of Hypertension |
| title | Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients |
| title_full | Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients |
| title_fullStr | Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients |
| title_full_unstemmed | Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients |
| title_short | Association between CD4 Cell Count and Blood Pressure and Its Variation with Body Mass Index Categories in HIV-Infected Patients |
| title_sort | association between cd4 cell count and blood pressure and its variation with body mass index categories in hiv infected patients |
| url | http://dx.doi.org/10.1155/2018/1691474 |
| work_keys_str_mv | AT christianakemdimala associationbetweencd4cellcountandbloodpressureanditsvariationwithbodymassindexcategoriesinhivinfectedpatients AT benjaminmomokadia associationbetweencd4cellcountandbloodpressureanditsvariationwithbodymassindexcategoriesinhivinfectedpatients AT benlawrencekemah associationbetweencd4cellcountandbloodpressureanditsvariationwithbodymassindexcategoriesinhivinfectedpatients AT maximetindong associationbetweencd4cellcountandbloodpressureanditsvariationwithbodymassindexcategoriesinhivinfectedpatients AT simeonpierrechoukem associationbetweencd4cellcountandbloodpressureanditsvariationwithbodymassindexcategoriesinhivinfectedpatients |