Network pharmacology mechanisms and experimental verification of Hedyotis Diffusae Herba-Scutellariae Barbatae Herba drug pair extract in the treatment of nasopharyngeal carcinoma

Network pharmacology mechanisms and experimental verification of Hedyotis Diffusae Herba-Scutellariae Barbatae Herba drug pair extract in the treatment of nasopharyngeal carcinoma

BackgroundNasopharyngeal carcinoma (NPC) represents the predominant head-neck malignancy in China. While the Hedyotis Diffusae Herba-Scutellariae Barbatae Herba (HDH-SBH) herb pair shows antitumor potential, its mechanism against NPC remains unclear.MethodsThis network pharmacology study integrated...

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Main Authors: Tiantian Li, Haijun Chen, Jing Zhang, Jiaxin Liu, Rundong Tang, Liang Zhang, Tian Feng, Yanchun Xiao, Shiwen Liu, Xiangjun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
drug pair
Hedyotis Diffusae Herba
nasopharyngeal carcinoma
network pharmacology
PI3K/Akt signaling pathway
Scutellariae barbatae herba
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1601725/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1601725/full

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