Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review
Surface Plasmon Resonance (SPR)-based biodetection systems have emerged as powerful tools for real-time, label-free biomolecular interaction analysis, revolutionizing fields such as diagnostics, drug discovery, and environmental monitoring. This review highlights the foundational principles of SPR,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/1/35 |
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| author | Muhammad A. Butt |
| author_facet | Muhammad A. Butt |
| author_sort | Muhammad A. Butt |
| collection | DOAJ |
| description | Surface Plasmon Resonance (SPR)-based biodetection systems have emerged as powerful tools for real-time, label-free biomolecular interaction analysis, revolutionizing fields such as diagnostics, drug discovery, and environmental monitoring. This review highlights the foundational principles of SPR, focusing on the interplay of evanescent waves and surface plasmons that underpin its high sensitivity and specificity. Recent advancements in SPR technology, including enhancements in sensor chip materials, integration with nanostructures, and coupling with complementary detection techniques, are discussed to showcase their role in improving analytical performance. The paper also explores diverse applications of SPR biodetection systems, ranging from pathogen detection and cancer biomarker identification to food safety monitoring and environmental toxin analysis. By providing a comprehensive overview of technological progress and emerging trends, this review underscores the transformative potential of SPR-based biodetection systems in addressing critical scientific and societal challenges. Future directions and challenges, including miniaturization, cost reduction, and expanding multiplexing capabilities, are also presented to guide ongoing research and development in this rapidly evolving field. |
| format | Article |
| id | doaj-art-b8c6d9855b1d4b08a858776e2aaa9448 |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-b8c6d9855b1d4b08a858776e2aaa94482025-01-24T13:25:30ZengMDPI AGBiosensors2079-63742025-01-011513510.3390/bios15010035Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive ReviewMuhammad A. Butt0Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, PolandSurface Plasmon Resonance (SPR)-based biodetection systems have emerged as powerful tools for real-time, label-free biomolecular interaction analysis, revolutionizing fields such as diagnostics, drug discovery, and environmental monitoring. This review highlights the foundational principles of SPR, focusing on the interplay of evanescent waves and surface plasmons that underpin its high sensitivity and specificity. Recent advancements in SPR technology, including enhancements in sensor chip materials, integration with nanostructures, and coupling with complementary detection techniques, are discussed to showcase their role in improving analytical performance. The paper also explores diverse applications of SPR biodetection systems, ranging from pathogen detection and cancer biomarker identification to food safety monitoring and environmental toxin analysis. By providing a comprehensive overview of technological progress and emerging trends, this review underscores the transformative potential of SPR-based biodetection systems in addressing critical scientific and societal challenges. Future directions and challenges, including miniaturization, cost reduction, and expanding multiplexing capabilities, are also presented to guide ongoing research and development in this rapidly evolving field.https://www.mdpi.com/2079-6374/15/1/35Surface Plasmon Resonanceplasmonicsbiodetection systemsfood safetyenvironmental monitoringdrug delivery |
| spellingShingle | Muhammad A. Butt Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review Biosensors Surface Plasmon Resonance plasmonics biodetection systems food safety environmental monitoring drug delivery |
| title | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review |
| title_full | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review |
| title_fullStr | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review |
| title_full_unstemmed | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review |
| title_short | Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications—A Comprehensive Review |
| title_sort | surface plasmon resonance based biodetection systems principles progress and applications a comprehensive review |
| topic | Surface Plasmon Resonance plasmonics biodetection systems food safety environmental monitoring drug delivery |
| url | https://www.mdpi.com/2079-6374/15/1/35 |
| work_keys_str_mv | AT muhammadabutt surfaceplasmonresonancebasedbiodetectionsystemsprinciplesprogressandapplicationsacomprehensivereview |