Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges
The human skin fulfills important barrier, sensory, and immune functions—all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, a...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/4623615 |
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| _version_ | 1832568025511886848 |
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| author | Inga Brockmann Juliet Ehrenpfordt Tabea Sturmheit Matthias Brandenburger Charli Kruse Marietta Zille Dorothee Rose Johannes Boltze |
| author_facet | Inga Brockmann Juliet Ehrenpfordt Tabea Sturmheit Matthias Brandenburger Charli Kruse Marietta Zille Dorothee Rose Johannes Boltze |
| author_sort | Inga Brockmann |
| collection | DOAJ |
| description | The human skin fulfills important barrier, sensory, and immune functions—all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. Since the skin is a highly immunocompetent organ, autologous transplants are the only viable approach to permanently close a widespread skin wound. Despite the development of tissue-saving autologous transplantation techniques such as mesh and Meek grafts, treatment options for extensive skin damage remain severely limited. Yet, the skin is also a rich source of stem and progenitor cells. These cells promote wound healing under physiological conditions and are potential sources for tissue engineering approaches aiming to augment transplantable tissue by generating cultured epidermal autografts (CEAs). Here, we review autologous tissue engineering strategies as well as transplantation products based on skin-derived stem cells. We further provide an overview of clinical trial activities in the field and discuss relevant translational and clinical challenges associated with the use of these products. |
| format | Article |
| id | doaj-art-b8c441c082e34271ae353e38f05e772f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-b8c441c082e34271ae353e38f05e772f2025-02-03T00:59:55ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/46236154623615Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and ChallengesInga Brockmann0Juliet Ehrenpfordt1Tabea Sturmheit2Matthias Brandenburger3Charli Kruse4Marietta Zille5Dorothee Rose6Johannes Boltze7Fraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyFraunhofer Research Institution for Marine Biotechnology and Cell Technology, Mönkhofer Weg 239a, 23562 Lübeck, GermanyThe human skin fulfills important barrier, sensory, and immune functions—all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. Since the skin is a highly immunocompetent organ, autologous transplants are the only viable approach to permanently close a widespread skin wound. Despite the development of tissue-saving autologous transplantation techniques such as mesh and Meek grafts, treatment options for extensive skin damage remain severely limited. Yet, the skin is also a rich source of stem and progenitor cells. These cells promote wound healing under physiological conditions and are potential sources for tissue engineering approaches aiming to augment transplantable tissue by generating cultured epidermal autografts (CEAs). Here, we review autologous tissue engineering strategies as well as transplantation products based on skin-derived stem cells. We further provide an overview of clinical trial activities in the field and discuss relevant translational and clinical challenges associated with the use of these products.http://dx.doi.org/10.1155/2018/4623615 |
| spellingShingle | Inga Brockmann Juliet Ehrenpfordt Tabea Sturmheit Matthias Brandenburger Charli Kruse Marietta Zille Dorothee Rose Johannes Boltze Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges Stem Cells International |
| title | Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges |
| title_full | Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges |
| title_fullStr | Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges |
| title_full_unstemmed | Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges |
| title_short | Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges |
| title_sort | skin derived stem cells for wound treatment using cultured epidermal autografts clinical applications and challenges |
| url | http://dx.doi.org/10.1155/2018/4623615 |
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