Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers
Abstract Proteins that bind to DNA/RNA are typically evolutionarily conserved with multiple regulatory functions in transcription initiation, mRNA translation, stability of RNAs, and RNA splicing. Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01087-8 |
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| author | Shiyi Yu Chengyang Jiang Yawen Yang Fei Cheng Fangchen Liu Chang Liu Xue Gong |
| author_facet | Shiyi Yu Chengyang Jiang Yawen Yang Fei Cheng Fangchen Liu Chang Liu Xue Gong |
| author_sort | Shiyi Yu |
| collection | DOAJ |
| description | Abstract Proteins that bind to DNA/RNA are typically evolutionarily conserved with multiple regulatory functions in transcription initiation, mRNA translation, stability of RNAs, and RNA splicing. Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). Most recently, several studies have revealed that PURα is dysregulated in multiple cancers, such as breast cancer (BC) and esophageal squamous cell carcinoma (ESCC). The oncogenic or tumor-suppressive functions of PURα are realized via regulating RNA/protein interaction, mRNA translation, formation of stress granules (SGs), and transcriptional regulation of several oncogenes and tumor suppressors. Although DNA/RNA binding proteins are hardly targeted, novel strategies have been applied to identify compounds targeting PURα and have demonstrated promising anti-tumor efficacy in the preclinical study. The present review summarizes the most recently discovered critical roles of PURα in various cancer types, providing an overview of the biomarker and therapeutic target potential of PURα for patients with cancer. |
| format | Article |
| id | doaj-art-b8b8f4bd97d74eafab0a544f3d0b6efe |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-b8b8f4bd97d74eafab0a544f3d0b6efe2025-01-26T12:38:41ZengBMCMolecular Medicine1528-36582025-01-0131111010.1186/s10020-025-01087-8Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancersShiyi Yu0Chengyang Jiang1Yawen Yang2Fei Cheng3Fangchen Liu4Chang Liu5Xue Gong6Institute of Translational Medicine, Medical College, Yangzhou UniversityInstitute of Translational Medicine, Medical College, Yangzhou UniversityInstitute of Translational Medicine, Medical College, Yangzhou UniversityInstitute of Translational Medicine, Medical College, Yangzhou UniversityInstitute of Translational Medicine, Medical College, Yangzhou UniversityInstitute of Translational Medicine, Medical College, Yangzhou UniversityNanjing Women and Children’s Healthcare Hospital, Maternal and Child Health Institute, Women’s Hospital of Nanjing Medical UniversityAbstract Proteins that bind to DNA/RNA are typically evolutionarily conserved with multiple regulatory functions in transcription initiation, mRNA translation, stability of RNAs, and RNA splicing. Therefore, dysregulation of DNA/RNA binding proteins such as purine-rich element binding protein alpha (PURα) disrupts signaling transduction and often leads to human diseases including cancer. PURα was initially recognized as a tumor suppressor in acute myeloid leukemia (AML) and prostate cancer (PC). Most recently, several studies have revealed that PURα is dysregulated in multiple cancers, such as breast cancer (BC) and esophageal squamous cell carcinoma (ESCC). The oncogenic or tumor-suppressive functions of PURα are realized via regulating RNA/protein interaction, mRNA translation, formation of stress granules (SGs), and transcriptional regulation of several oncogenes and tumor suppressors. Although DNA/RNA binding proteins are hardly targeted, novel strategies have been applied to identify compounds targeting PURα and have demonstrated promising anti-tumor efficacy in the preclinical study. The present review summarizes the most recently discovered critical roles of PURα in various cancer types, providing an overview of the biomarker and therapeutic target potential of PURα for patients with cancer.https://doi.org/10.1186/s10020-025-01087-8DNA/RNA binding proteinPURαCancerBiomarker |
| spellingShingle | Shiyi Yu Chengyang Jiang Yawen Yang Fei Cheng Fangchen Liu Chang Liu Xue Gong Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers Molecular Medicine DNA/RNA binding protein PURα Cancer Biomarker |
| title | Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers |
| title_full | Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers |
| title_fullStr | Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers |
| title_full_unstemmed | Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers |
| title_short | Purine-rich element binding protein alpha: a DNA/RNA binding protein with multiple roles in cancers |
| title_sort | purine rich element binding protein alpha a dna rna binding protein with multiple roles in cancers |
| topic | DNA/RNA binding protein PURα Cancer Biomarker |
| url | https://doi.org/10.1186/s10020-025-01087-8 |
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