Designing hydrogel for application in spinal surgery

Spinal diseases and injuries are prevalent in clinical settings and impose a substantial burden on healthcare systems. Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conservative treatments. Generally, these treatment modalities have...

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Main Authors: Rongpeng Dong, Shuang Zheng, Xueliang Cheng
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Materials Today Bio
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Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425000948
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author Rongpeng Dong
Shuang Zheng
Xueliang Cheng
author_facet Rongpeng Dong
Shuang Zheng
Xueliang Cheng
author_sort Rongpeng Dong
collection DOAJ
description Spinal diseases and injuries are prevalent in clinical settings and impose a substantial burden on healthcare systems. Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conservative treatments. Generally, these treatment modalities have limited or no long-term benefits. Hydrogel-based treatments have emerged as potentially powerful paradigms for improving therapeutic outcomes and the quality of life of patients. Hydrogels can be injected into target sites, including the epidural, intraspinal, and nucleus pulposus spaces, in a minimally invasive manner and fill defects to provide mechanical support. Hydrogels can be designed for the localized and controlled delivery of pharmacological agents to enhance therapeutic effects and reduce adverse reactions. Hydrogels can act as structural supports for transplanted cells to improve cell survival, proliferation, and differentiation, as well as integration into adjacent host tissues. In this review, we summarize recent advances in the design of hydrogels for the treatment of spinal diseases and injuries commonly found in clinical settings, including intervertebral disc degeneration, spinal cord injury, and dural membrane injury. We introduce the design considerations for different hydrogel systems, including precursor polymers and crosslinking mechanisms. Herein, we discuss the therapeutic outcomes of these hydrogels in terms of providing mechanical support, delivering cells/bioactive agents, regulating local inflammation, and promoting tissue regeneration and functional recovery.
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spelling doaj-art-b8976d9b131d4c1e9a065fe80133aafa2025-02-06T05:12:41ZengElsevierMaterials Today Bio2590-00642025-04-0131101536Designing hydrogel for application in spinal surgeryRongpeng Dong0Shuang Zheng1Xueliang Cheng2Department of Orthopedics, The Second Norman Bethune Hospital of Jilin University, Changchun, 130014, Jilin, ChinaDepartment of Orthopedics, The Second Norman Bethune Hospital of Jilin University, Changchun, 130014, Jilin, ChinaCorresponding author.; Department of Orthopedics, The Second Norman Bethune Hospital of Jilin University, Changchun, 130014, Jilin, ChinaSpinal diseases and injuries are prevalent in clinical settings and impose a substantial burden on healthcare systems. Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conservative treatments. Generally, these treatment modalities have limited or no long-term benefits. Hydrogel-based treatments have emerged as potentially powerful paradigms for improving therapeutic outcomes and the quality of life of patients. Hydrogels can be injected into target sites, including the epidural, intraspinal, and nucleus pulposus spaces, in a minimally invasive manner and fill defects to provide mechanical support. Hydrogels can be designed for the localized and controlled delivery of pharmacological agents to enhance therapeutic effects and reduce adverse reactions. Hydrogels can act as structural supports for transplanted cells to improve cell survival, proliferation, and differentiation, as well as integration into adjacent host tissues. In this review, we summarize recent advances in the design of hydrogels for the treatment of spinal diseases and injuries commonly found in clinical settings, including intervertebral disc degeneration, spinal cord injury, and dural membrane injury. We introduce the design considerations for different hydrogel systems, including precursor polymers and crosslinking mechanisms. Herein, we discuss the therapeutic outcomes of these hydrogels in terms of providing mechanical support, delivering cells/bioactive agents, regulating local inflammation, and promoting tissue regeneration and functional recovery.http://www.sciencedirect.com/science/article/pii/S2590006425000948Biomedical hydrogelSpinal surgeryIntervertebral disc degenerationSpinal cord injuryDural sealing
spellingShingle Rongpeng Dong
Shuang Zheng
Xueliang Cheng
Designing hydrogel for application in spinal surgery
Materials Today Bio
Biomedical hydrogel
Spinal surgery
Intervertebral disc degeneration
Spinal cord injury
Dural sealing
title Designing hydrogel for application in spinal surgery
title_full Designing hydrogel for application in spinal surgery
title_fullStr Designing hydrogel for application in spinal surgery
title_full_unstemmed Designing hydrogel for application in spinal surgery
title_short Designing hydrogel for application in spinal surgery
title_sort designing hydrogel for application in spinal surgery
topic Biomedical hydrogel
Spinal surgery
Intervertebral disc degeneration
Spinal cord injury
Dural sealing
url http://www.sciencedirect.com/science/article/pii/S2590006425000948
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AT shuangzheng designinghydrogelforapplicationinspinalsurgery
AT xueliangcheng designinghydrogelforapplicationinspinalsurgery