Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones
Abstract This study examined the relationship between gallstones and estimated glucose disposal rate (eGDR) in people in the United States and the possible mediating function of body mass index (BMI). Data came from the National Health and Nutrition Examination Survey (NHANES), conducted between 201...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86708-2 |
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| author | Shuaipeng Yuan Yuexia Lu Zhun Xiao Suping Ma |
| author_facet | Shuaipeng Yuan Yuexia Lu Zhun Xiao Suping Ma |
| author_sort | Shuaipeng Yuan |
| collection | DOAJ |
| description | Abstract This study examined the relationship between gallstones and estimated glucose disposal rate (eGDR) in people in the United States and the possible mediating function of body mass index (BMI). Data came from the National Health and Nutrition Examination Survey (NHANES), conducted between 2017 and March 2020. Logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation studies were among the statistical techniques used to examine the participant data. There were 595 subjects with a gallstone diagnosis out of 5,656 total. A significant negative association between eGDR and gallstones was observed by fully adjusted multivariate logistic regression analysis with an OR of 0.90 and a 95% confidence interval (CI) of (0.83, 0.98). The mediation analysis indicated that BMI accounted for 58.58% of the relationship between eGDR and the occurrence of gallstones. This study identified a substantial non-linear negative relationship between the occurrence of gallstones and eGDR levels, with BMI acting as a mediating factor. A fresh viewpoint on gallstone therapy and prevention is offered by these findings. |
| format | Article |
| id | doaj-art-b865cbe492f24f9598c33d2632ae9c56 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-b865cbe492f24f9598c33d2632ae9c562025-01-19T12:22:55ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86708-2Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstonesShuaipeng Yuan0Yuexia Lu1Zhun Xiao2Suping Ma3Department of Digestive Diseases, The First Affiliated Hospital of Henan University of Chinese MedicineDepartment of Digestive Diseases, Guang ’anmen Hospital, China Academy of Chinese Medical SciencesDepartment of Digestive Diseases, The First Affiliated Hospital of Henan University of Chinese MedicineDepartment of Digestive Diseases, The First Affiliated Hospital of Henan University of Chinese MedicineAbstract This study examined the relationship between gallstones and estimated glucose disposal rate (eGDR) in people in the United States and the possible mediating function of body mass index (BMI). Data came from the National Health and Nutrition Examination Survey (NHANES), conducted between 2017 and March 2020. Logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation studies were among the statistical techniques used to examine the participant data. There were 595 subjects with a gallstone diagnosis out of 5,656 total. A significant negative association between eGDR and gallstones was observed by fully adjusted multivariate logistic regression analysis with an OR of 0.90 and a 95% confidence interval (CI) of (0.83, 0.98). The mediation analysis indicated that BMI accounted for 58.58% of the relationship between eGDR and the occurrence of gallstones. This study identified a substantial non-linear negative relationship between the occurrence of gallstones and eGDR levels, with BMI acting as a mediating factor. A fresh viewpoint on gallstone therapy and prevention is offered by these findings.https://doi.org/10.1038/s41598-025-86708-2GallstonesBody Mass IndexEstimated glucose disposal rateNational Health and Nutrition Examination Survey |
| spellingShingle | Shuaipeng Yuan Yuexia Lu Zhun Xiao Suping Ma Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones Scientific Reports Gallstones Body Mass Index Estimated glucose disposal rate National Health and Nutrition Examination Survey |
| title | Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones |
| title_full | Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones |
| title_fullStr | Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones |
| title_full_unstemmed | Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones |
| title_short | Body Mass Index mediates the relationship between estimated glucose disposal rate and gallstones |
| title_sort | body mass index mediates the relationship between estimated glucose disposal rate and gallstones |
| topic | Gallstones Body Mass Index Estimated glucose disposal rate National Health and Nutrition Examination Survey |
| url | https://doi.org/10.1038/s41598-025-86708-2 |
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