MergeReference: A Tool for Merging Reference Panels for HLA Imputation
Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the referenc...
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| Format: | Article |
| Language: | English |
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BioMed Central
2017-09-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/GI-2017-15-3-108.pdf |
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| _version_ | 1832573717150957568 |
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| author | Seungho Cook Buhm Han |
| author_facet | Seungho Cook Buhm Han |
| author_sort | Seungho Cook |
| collection | DOAJ |
| description | Recently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one. |
| format | Article |
| id | doaj-art-b85b4aa3bee24013968bf4ef8ef5e5f1 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-b85b4aa3bee24013968bf4ef8ef5e5f12025-02-02T03:13:31ZengBioMed CentralGenomics & Informatics2234-07422017-09-0115310811110.5808/GI.2017.15.3.108491MergeReference: A Tool for Merging Reference Panels for HLA ImputationSeungho CookBuhm Han0 Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, KoreaRecently developed computational methods allow the imputation of human leukocyte antigen (HLA) genes using intergenic single nucleotide polymorphism markers. To improve the imputation accuracy in HLA imputation, it is essential to increase the sample size and the diversity of alleles in the reference panel. Our software, MergeReference, helps achieve this goal by providing a streamlined pipeline for combining multiple reference panels into one.http://genominfo.org/upload/pdf/GI-2017-15-3-108.pdfhuman leukocyte antigensmajor histocompatibility complex |
| spellingShingle | Seungho Cook Buhm Han MergeReference: A Tool for Merging Reference Panels for HLA Imputation Genomics & Informatics human leukocyte antigens major histocompatibility complex |
| title | MergeReference: A Tool for Merging Reference Panels for HLA Imputation |
| title_full | MergeReference: A Tool for Merging Reference Panels for HLA Imputation |
| title_fullStr | MergeReference: A Tool for Merging Reference Panels for HLA Imputation |
| title_full_unstemmed | MergeReference: A Tool for Merging Reference Panels for HLA Imputation |
| title_short | MergeReference: A Tool for Merging Reference Panels for HLA Imputation |
| title_sort | mergereference a tool for merging reference panels for hla imputation |
| topic | human leukocyte antigens major histocompatibility complex |
| url | http://genominfo.org/upload/pdf/GI-2017-15-3-108.pdf |
| work_keys_str_mv | AT seunghocook mergereferenceatoolformergingreferencepanelsforhlaimputation AT buhmhan mergereferenceatoolformergingreferencepanelsforhlaimputation |