Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation
Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3728096 |
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| author | Audrey Ortega-Ramírez Rosario Vega Enrique Soto |
| author_facet | Audrey Ortega-Ramírez Rosario Vega Enrique Soto |
| author_sort | Audrey Ortega-Ramírez |
| collection | DOAJ |
| description | Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues. Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain. |
| format | Article |
| id | doaj-art-b85aef1479b24d908062175dda95f30e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b85aef1479b24d908062175dda95f30e2025-02-03T01:09:36ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/37280963728096Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and NeuroinflammationAudrey Ortega-Ramírez0Rosario Vega1Enrique Soto2Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 sur 6301, CU, San Manuel, 72570 Puebla, PUE, MexicoInstituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 sur 6301, CU, San Manuel, 72570 Puebla, PUE, MexicoInstituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 sur 6301, CU, San Manuel, 72570 Puebla, PUE, MexicoAcid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues. Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.http://dx.doi.org/10.1155/2017/3728096 |
| spellingShingle | Audrey Ortega-Ramírez Rosario Vega Enrique Soto Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation Mediators of Inflammation |
| title | Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation |
| title_full | Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation |
| title_fullStr | Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation |
| title_full_unstemmed | Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation |
| title_short | Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation |
| title_sort | acid sensing ion channels as potential therapeutic targets in neurodegeneration and neuroinflammation |
| url | http://dx.doi.org/10.1155/2017/3728096 |
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