Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes
Cardiovascular complications associated with diabetes remain a significant health issue in westernized societies. Overwhelming evidence from clinical and laboratory investigations have demonstrated that these cardiovascular complications are initiated by a dysfunctional vascular endothelium. Indeed,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Vascular Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/750126 |
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| _version_ | 1832547105505280000 |
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| author | Arpeeta Sharma Pascal N. Bernatchez Judy B. de Haan |
| author_facet | Arpeeta Sharma Pascal N. Bernatchez Judy B. de Haan |
| author_sort | Arpeeta Sharma |
| collection | DOAJ |
| description | Cardiovascular complications associated with diabetes remain a significant health issue in westernized societies. Overwhelming evidence from clinical and laboratory investigations have demonstrated that these cardiovascular complications are initiated by a dysfunctional vascular endothelium. Indeed, endothelial dysfunction is one of the key events that occur during diabetes, leading to the acceleration of cardiovascular mortality and morbidity. In a diabetic milieu, endothelial dysfunction occurs as a result of attenuated production of endothelial derived nitric oxide (EDNO) and augmented levels of reactive oxygen species (ROS). Thus, in this review, we discuss novel therapeutic targets that either upregulate EDNO production or increase antioxidant enzyme capacity in an effort to limit oxidative stress and restore endothelial function. In particular, endogenous signaling molecules that positively modulate EDNO synthesis and mimetics of endogenous antioxidant enzymes will be highlighted. Consequently, manipulation of these unique targets, either alone or in combination, may represent a novel strategy to confer vascular protection, with the ultimate goal of improved outcomes for diabetes-associated vascular complications. |
| format | Article |
| id | doaj-art-b849a41c54804afe9d0a0aa1c6f31de8 |
| institution | Kabale University |
| issn | 2090-2824 2090-2832 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Vascular Medicine |
| spelling | doaj-art-b849a41c54804afe9d0a0aa1c6f31de82025-02-03T06:46:03ZengWileyInternational Journal of Vascular Medicine2090-28242090-28322012-01-01201210.1155/2012/750126750126Targeting Endothelial Dysfunction in Vascular Complications Associated with DiabetesArpeeta Sharma0Pascal N. Bernatchez1Judy B. de Haan2Oxidative Stress Laboratory, Diabetic Complications Division, Baker IDI Heart and Diabetes Institute, P.O. Box 6492, St. Kilda Road Central, Melbourne, VIC 8008, AustraliaThe James Hogg Research Centre at St. Paul's Hospital and Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, V6Z 1Y6, CanadaOxidative Stress Laboratory, Diabetic Complications Division, Baker IDI Heart and Diabetes Institute, P.O. Box 6492, St. Kilda Road Central, Melbourne, VIC 8008, AustraliaCardiovascular complications associated with diabetes remain a significant health issue in westernized societies. Overwhelming evidence from clinical and laboratory investigations have demonstrated that these cardiovascular complications are initiated by a dysfunctional vascular endothelium. Indeed, endothelial dysfunction is one of the key events that occur during diabetes, leading to the acceleration of cardiovascular mortality and morbidity. In a diabetic milieu, endothelial dysfunction occurs as a result of attenuated production of endothelial derived nitric oxide (EDNO) and augmented levels of reactive oxygen species (ROS). Thus, in this review, we discuss novel therapeutic targets that either upregulate EDNO production or increase antioxidant enzyme capacity in an effort to limit oxidative stress and restore endothelial function. In particular, endogenous signaling molecules that positively modulate EDNO synthesis and mimetics of endogenous antioxidant enzymes will be highlighted. Consequently, manipulation of these unique targets, either alone or in combination, may represent a novel strategy to confer vascular protection, with the ultimate goal of improved outcomes for diabetes-associated vascular complications.http://dx.doi.org/10.1155/2012/750126 |
| spellingShingle | Arpeeta Sharma Pascal N. Bernatchez Judy B. de Haan Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes International Journal of Vascular Medicine |
| title | Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes |
| title_full | Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes |
| title_fullStr | Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes |
| title_full_unstemmed | Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes |
| title_short | Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes |
| title_sort | targeting endothelial dysfunction in vascular complications associated with diabetes |
| url | http://dx.doi.org/10.1155/2012/750126 |
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