Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue
Abstract Current literature regarding cancer risk in rheumatic and musculoskeletal diseases (RMDs) is particularly poor and controversial, even though the incidence of malignancy in some patients with RMDs is considered to be increased compared with the general population. Malignancy may be a major...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-12-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40744-024-00734-6 |
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| author | Ennio Giulio Favalli Francesco Grossi Alberto Batticciotto Matteo Filippini Simone Parisi Ombretta Viapiana Paolo Gisondi Paolo Dapavo Lorenzo Dagna Filippo De Braud |
| author_facet | Ennio Giulio Favalli Francesco Grossi Alberto Batticciotto Matteo Filippini Simone Parisi Ombretta Viapiana Paolo Gisondi Paolo Dapavo Lorenzo Dagna Filippo De Braud |
| author_sort | Ennio Giulio Favalli |
| collection | DOAJ |
| description | Abstract Current literature regarding cancer risk in rheumatic and musculoskeletal diseases (RMDs) is particularly poor and controversial, even though the incidence of malignancy in some patients with RMDs is considered to be increased compared with the general population. Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. Several recommendations for screening and management of cancer risk have been developed in recent years with the aim of improving the different outcomes in these patients. The goal of this narrative review is to provide an overview of the currently available evidence on the risk of malignancy connected with RMDs and examine the association of SpA with cancer and the potential impact of its treatment with biologic and targeted synthetic disease-modifying anti-rheumatic drugs on development of malignancy. |
| format | Article |
| id | doaj-art-b83f35bf7e024386ac5c182ada8cb7a7 |
| institution | Kabale University |
| issn | 2198-6576 2198-6584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj-art-b83f35bf7e024386ac5c182ada8cb7a72025-01-26T12:52:11ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842024-12-01121253610.1007/s40744-024-00734-6Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial IssueEnnio Giulio Favalli0Francesco Grossi1Alberto Batticciotto2Matteo Filippini3Simone Parisi4Ombretta Viapiana5Paolo Gisondi6Paolo Dapavo7Lorenzo Dagna8Filippo De Braud9Department of Rheumatology and Medical Sciences, ASST Gaetano Pini-CTODepartment of Medicine and Technological Innovation, Università degli Studi dell’InsubriaRheumatology Unit, Internal Medicine Department, ASST Sette Laghi, Ospedale Di Circolo, Fondazione MacchiRheumatology and Clinical Immunology Unit-ERN ReCONNET, ASST Spedali CiviliRheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e Della Scienza di TorinoRheumatology Unit, Department of Medicine, University of VeronaSection of Dermatology and Venereology, Department of Medicine, University of VeronaSection of Dermatology, Department of Medical Sciences, University of TurinUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific InstituteUniversity of Milan, Fondazione IRCCS Istituto Nazionale del TumoriAbstract Current literature regarding cancer risk in rheumatic and musculoskeletal diseases (RMDs) is particularly poor and controversial, even though the incidence of malignancy in some patients with RMDs is considered to be increased compared with the general population. Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. Several recommendations for screening and management of cancer risk have been developed in recent years with the aim of improving the different outcomes in these patients. The goal of this narrative review is to provide an overview of the currently available evidence on the risk of malignancy connected with RMDs and examine the association of SpA with cancer and the potential impact of its treatment with biologic and targeted synthetic disease-modifying anti-rheumatic drugs on development of malignancy.https://doi.org/10.1007/s40744-024-00734-6Anti-rheumatic drugsCancer riskMalignancyScreeningSpondyloarthritis |
| spellingShingle | Ennio Giulio Favalli Francesco Grossi Alberto Batticciotto Matteo Filippini Simone Parisi Ombretta Viapiana Paolo Gisondi Paolo Dapavo Lorenzo Dagna Filippo De Braud Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue Rheumatology and Therapy Anti-rheumatic drugs Cancer risk Malignancy Screening Spondyloarthritis |
| title | Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue |
| title_full | Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue |
| title_fullStr | Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue |
| title_full_unstemmed | Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue |
| title_short | Spondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue |
| title_sort | spondyloarthritis and risk of malignancy a narrative review on a still controversial issue |
| topic | Anti-rheumatic drugs Cancer risk Malignancy Screening Spondyloarthritis |
| url | https://doi.org/10.1007/s40744-024-00734-6 |
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