Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure
Purpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods. In this prospective case series, ECD was evaluated by noncontact specular microscopy and...
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/6368784 |
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| author | Carlo Alberto Cutolo Chiara Bonzano Carlo Catti Alessandro Bagnis Riccardo Scotto Letizia Negri Sara Olivari Francesca Cappelli Carlo Enrico Traverso |
| author_facet | Carlo Alberto Cutolo Chiara Bonzano Carlo Catti Alessandro Bagnis Riccardo Scotto Letizia Negri Sara Olivari Francesca Cappelli Carlo Enrico Traverso |
| author_sort | Carlo Alberto Cutolo |
| collection | DOAJ |
| description | Purpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods. In this prospective case series, ECD was evaluated by noncontact specular microscopy and biometric parameters by both noncontact optical biometry and anterior segment optical coherence tomography, preoperatively and at 12 months after surgery. Anterior segment biomicroscopy and gonioscopy were also performed. The change in ECD and its relation to clinical characteristics and biometric parameters were evaluated by linear regression analysis. Results. 44 patients with PAC were included in the study. The mean (SD) patient age was 71.6 (10.2) years; thirty-one (70.5%) of them were women. Coexistence of exfoliation syndrome (XS) was observed in 4 cases (9.1%). The mean (SD) ECD (cells/mm2) changed from 2275 (463) preoperatively to 1964 (613) postoperatively with a mean reduction of −310 (95% CI −445 to −176; p<0.001). In the multivariate regression model, after correction for age and lens status, XS was the only parameter associated with ECD percentage change (B = −36.00; p=0.001). Conclusion. PE in angle closure causes a significant ECD reduction. In our population of PAC patients, XS is significantly associated with ECD change. In this group of patients, a careful preoperative endothelial evaluation should be performed. |
| format | Article |
| id | doaj-art-b83e54ac1f0a4725aee4c72aae435604 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-b83e54ac1f0a4725aee4c72aae4356042025-02-03T00:59:45ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/63687846368784Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle ClosureCarlo Alberto Cutolo0Chiara Bonzano1Carlo Catti2Alessandro Bagnis3Riccardo Scotto4Letizia Negri5Sara Olivari6Francesca Cappelli7Carlo Enrico Traverso8Clinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyClinica Oculistica, DiNOGMI, University of Genoa and IRCCS San Martino Policlinic Hospital, Genova, ItalyPurpose. To investigate demographic and anatomical factors associated with a reduction in endothelial cell density (ECD) after phacoemulsification (PE) for the treatment of primary angle closure (PAC). Methods. In this prospective case series, ECD was evaluated by noncontact specular microscopy and biometric parameters by both noncontact optical biometry and anterior segment optical coherence tomography, preoperatively and at 12 months after surgery. Anterior segment biomicroscopy and gonioscopy were also performed. The change in ECD and its relation to clinical characteristics and biometric parameters were evaluated by linear regression analysis. Results. 44 patients with PAC were included in the study. The mean (SD) patient age was 71.6 (10.2) years; thirty-one (70.5%) of them were women. Coexistence of exfoliation syndrome (XS) was observed in 4 cases (9.1%). The mean (SD) ECD (cells/mm2) changed from 2275 (463) preoperatively to 1964 (613) postoperatively with a mean reduction of −310 (95% CI −445 to −176; p<0.001). In the multivariate regression model, after correction for age and lens status, XS was the only parameter associated with ECD percentage change (B = −36.00; p=0.001). Conclusion. PE in angle closure causes a significant ECD reduction. In our population of PAC patients, XS is significantly associated with ECD change. In this group of patients, a careful preoperative endothelial evaluation should be performed.http://dx.doi.org/10.1155/2019/6368784 |
| spellingShingle | Carlo Alberto Cutolo Chiara Bonzano Carlo Catti Alessandro Bagnis Riccardo Scotto Letizia Negri Sara Olivari Francesca Cappelli Carlo Enrico Traverso Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure Journal of Ophthalmology |
| title | Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure |
| title_full | Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure |
| title_fullStr | Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure |
| title_full_unstemmed | Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure |
| title_short | Predictors of Endothelial Cell Loss after Phacoemulsification for the Treatment of Primary Angle Closure |
| title_sort | predictors of endothelial cell loss after phacoemulsification for the treatment of primary angle closure |
| url | http://dx.doi.org/10.1155/2019/6368784 |
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