Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation

Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation

Diabetes mellitus is a chronic illness that needs persistent medical attention and continuous patient self-management to avoid acute complications. Dipeptidyl peptidase-IV (DPP-IV) inhibitors minimize glucagon and blood glucose levels by increasing the incretin levels, glucagon-like peptide (GLP-1)...

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Bibliographic Details
Main Authors: Khalaf Reema Abu, Alwarafi Ebtisam, Sabbah Dima
Format: Article
Language:English
Published: Sciendo 2021-12-01
Series:Acta Pharmaceutica
Subjects:
piperazine sulfonamide
dipeptidyl peptidase-iv inhibitor
diabetes mellitus
induced-fit docking
Online Access:https://doi.org/10.2478/acph-2021-0034
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https://doi.org/10.2478/acph-2021-0034

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