Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21

Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21

Down syndrome (DS), a genetic condition caused by trisomy 21 (T21), manifests various neurological symptoms, including intellectual disability, early neurodegeneration, and early-onset dementia. N-glycosylation is a protein modification that plays a critical role in numerous neurobiological processe...

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Bibliographic Details
Main Authors: Ana Cindrić, Frano Vučković, Aoife Murray, Thomas S. Klarić, Ivan Alić, Jasminka Krištić, Dean Nižetić, Gordan Lauc
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:BBA Advances
Subjects:
N-glycosylation
iPSC
NSC
Down syndrome
Trisomy 21
Cellular differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2667160324000255
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