Synthesis and anti-proliferative studies of 2-acyl-4-(het)arylthiazoles on human hepatoma cells

Synthesis and anti-proliferative studies of 2-acyl-4-(het)arylthiazoles on human hepatoma cells

We herein report an improved protocol for the synthesis of 2-acyl-4-(het)arylthiazoles by reacting α-oxothioamides with α-bromocarbonyl compounds in acetonitrile under microwave irradiation. One of the thiazoles, (4-(4-bromophenyl)thiazol-2-yl)(m-tolyl)methanone (SW-07) has emerged as the best cytot...

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Bibliographic Details
Main Authors: Rajaghatta N. Suresh, Prasanna Doddakunche Shivaramu, Toreshettahally R. Swaroop, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Chandra Sekhar Bhol, Kwang Seok Ahn, Kempegowda Mantelingu, Kanchugarakoppal S. Rangappa
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Results in Chemistry
Subjects:
Thiazoles
Anticancer
Hepatoma
Anti-proliferative
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S221171562500582X
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