The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats
Background and Aim: Gold nanoparticles (GNPs) are widely used in industrial and medical applications due to their unique properties but may induce oxidative stress and hepatotoxicity. Propolis, a bee-derived natural product with potent antioxidant and anti-inflammatory properties, shows promise as a...
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Veterinary World
2025-02-01
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| Series: | Veterinary World |
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| Online Access: | https://www.veterinaryworld.org/Vol.18/February-2025/1.pdf |
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| author | Sarah A. Althubyani |
| author_facet | Sarah A. Althubyani |
| author_sort | Sarah A. Althubyani |
| collection | DOAJ |
| description | Background and Aim: Gold nanoparticles (GNPs) are widely used in industrial and medical applications due to their unique properties but may induce oxidative stress and hepatotoxicity. Propolis, a bee-derived natural product with potent antioxidant and anti-inflammatory properties, shows promise as a hepatoprotective agent. This study evaluates the protective effects of Saudi propolis against GNP-induced hepatic damage by examining oxidative stress, lipid metabolism, and liver function. This study aimed to investigate the hepatoprotective effects of Saudi propolis against oxidative damage and lipid dysregulation induced by GNPs in male albino rats.
Materials and Methods: A total of 180 adult male rats were divided into six groups: (1) Control (saline), (2) Propolis (100 mg/kg), (3) GNPs (10 nm, 0.2 mg/kg/day), (4) GNPs (30 nm, 0.2 mg/kg/day), (5) GNPs (10 nm) + propolis, and (6) GNPs (30 nm) + propolis. Treatments were administered daily for 5, 10, or 15 days. Blood and liver samples were analyzed for oxidative stress markers, liver enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, and glutamyl transpeptidase), lipid peroxidation (malondialdehyde [MDA]), antioxidant enzymes (superoxide dismutase [SOD] and glutathione peroxides [GPx]), and lipid profiles (cholesterol [CHO] and triglyceride [TG]).
Results: Rats treated with GNPs showed elevated liver enzymes, lipid peroxidation, and oxidative stress, accompanied by increased CHO and TG levels. In contrast, co-administration of Saudi propolis significantly mitigated these effects, restoring MDA, SOD, and GPx levels close to control values. The hepatoprotective effects were more pronounced for 10 nm GNPs than 30 nm. After 15 days, TG levels returned to near-normal levels, while CHO levels improved but remained elevated.
Conclusion: Saudi propolis exhibits significant protective effects against GNP-induced hepatic damage, primarily due to its antioxidant properties and ability to reduce oxidative stress and lipid peroxidation. The findings provide evidence for the therapeutic potential of propolis in managing nanoparticle-induced liver toxicity. |
| format | Article |
| id | doaj-art-b7df9eeec78c47ddb9b97b7c8c8f7c06 |
| institution | OA Journals |
| issn | 0972-8988 2231-0916 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj-art-b7df9eeec78c47ddb9b97b7c8c8f7c062025-08-20T02:14:27ZengVeterinary WorldVeterinary World0972-89882231-09162025-02-0118225226210.14202/vetworld.2025.252-262The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino ratsSarah A. Althubyani0Department of Biology. College of Science. Taibah University, Madinah, Saudi Arabia.Background and Aim: Gold nanoparticles (GNPs) are widely used in industrial and medical applications due to their unique properties but may induce oxidative stress and hepatotoxicity. Propolis, a bee-derived natural product with potent antioxidant and anti-inflammatory properties, shows promise as a hepatoprotective agent. This study evaluates the protective effects of Saudi propolis against GNP-induced hepatic damage by examining oxidative stress, lipid metabolism, and liver function. This study aimed to investigate the hepatoprotective effects of Saudi propolis against oxidative damage and lipid dysregulation induced by GNPs in male albino rats. Materials and Methods: A total of 180 adult male rats were divided into six groups: (1) Control (saline), (2) Propolis (100 mg/kg), (3) GNPs (10 nm, 0.2 mg/kg/day), (4) GNPs (30 nm, 0.2 mg/kg/day), (5) GNPs (10 nm) + propolis, and (6) GNPs (30 nm) + propolis. Treatments were administered daily for 5, 10, or 15 days. Blood and liver samples were analyzed for oxidative stress markers, liver enzymes (aspartate transaminase, alanine transaminase, alkaline phosphatase, and glutamyl transpeptidase), lipid peroxidation (malondialdehyde [MDA]), antioxidant enzymes (superoxide dismutase [SOD] and glutathione peroxides [GPx]), and lipid profiles (cholesterol [CHO] and triglyceride [TG]). Results: Rats treated with GNPs showed elevated liver enzymes, lipid peroxidation, and oxidative stress, accompanied by increased CHO and TG levels. In contrast, co-administration of Saudi propolis significantly mitigated these effects, restoring MDA, SOD, and GPx levels close to control values. The hepatoprotective effects were more pronounced for 10 nm GNPs than 30 nm. After 15 days, TG levels returned to near-normal levels, while CHO levels improved but remained elevated. Conclusion: Saudi propolis exhibits significant protective effects against GNP-induced hepatic damage, primarily due to its antioxidant properties and ability to reduce oxidative stress and lipid peroxidation. The findings provide evidence for the therapeutic potential of propolis in managing nanoparticle-induced liver toxicity.https://www.veterinaryworld.org/Vol.18/February-2025/1.pdfantioxidantsgold nanoparticleshepatotoxicitylipid metabolismoxidative stressratssaudi propolis |
| spellingShingle | Sarah A. Althubyani The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats Veterinary World antioxidants gold nanoparticles hepatotoxicity lipid metabolism oxidative stress rats saudi propolis |
| title | The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| title_full | The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| title_fullStr | The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| title_full_unstemmed | The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| title_short | The protective effects of Saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| title_sort | protective effects of saudi propolis against hepatic injury induced by gold nanoparticles in adult male albino rats |
| topic | antioxidants gold nanoparticles hepatotoxicity lipid metabolism oxidative stress rats saudi propolis |
| url | https://www.veterinaryworld.org/Vol.18/February-2025/1.pdf |
| work_keys_str_mv | AT sarahaalthubyani theprotectiveeffectsofsaudipropolisagainsthepaticinjuryinducedbygoldnanoparticlesinadultmalealbinorats AT sarahaalthubyani protectiveeffectsofsaudipropolisagainsthepaticinjuryinducedbygoldnanoparticlesinadultmalealbinorats |