Knockout of Sirtuin 3 in endothelial cells impairs endothelial‐dependent relaxation and myogenic response in mice

Abstract Sirtuin 3 has been shown to regulate endothelial function and coronary flow reserve in mice. Knockout of SIRT3 reduced endothelial nitric oxide synthase expression in the mouse hearts. In this study, we investigate whether endothelial SIRT3 regulates vascular function and myogenic responses...

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Bibliographic Details
Main Authors: Jian‐Xiong Chen, Jin Zhang, Yingjie Chen, Heng Zeng
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.70060
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