Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice

Polyhexamethylene Guanidine Phosphate Induces Restrictive Ventilation Defect and Alters Lung Resistance and Compliance in Mice

Polyhexamethylene guanidine phosphate (PHMG-p), a major ingredient of humidifier disinfectants, is known to induce inflammation, interstitial pneumonitis, and fibrosis in the lungs. While its histopathologic toxicities have been studied in rodents, research on pulmonary function test (PFT) changes f...

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Bibliographic Details
Main Authors: Yoon Hee Park, Sang-Hoon Jeong, Hong Lee, Yoon-Jeong Nam, Hyejin Lee, Yu-Seon Lee, Jin-Young Choi, Su-A Park, Mi-Jin Choi, Hayan Park, Jaeyoung Kim, Eun-Yeob Kim, Yong-Wook Baek, Jungyun Lim, Sua Kim, Je-Hyeong Kim, Ju-Han Lee
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Toxics
Subjects:
polyhexamethylene guanidine phosphate
pulmonary function test
fibrosis
mouse
Online Access:https://www.mdpi.com/2305-6304/12/11/776
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