Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts

Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts

Abstract To elucidate the role of IGF1R inhibition in the pathogenesis of Graves’ orbitopathy (GO), the effects of linsitinib (Lins) on a recombinant human TSHR antibody (M22) and IGF1 to activate TSHR and IGF1R of human orbital fibroblasts (HOFs) obtained from patients without GO (HOFs) and patient...

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Main Authors: Fumihito Hikage, Megumi Suzuki, Tatsuya Sato, Araya Umetsu, Toshifumi Ogawa, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro, Megumi Watanabe
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Three-dimensional (3D) cell culture
Graves’ orbitopathy
IGF-1
Orbital fibroblast
Linsitinib
M22
Online Access:https://doi.org/10.1038/s41598-024-83193-x
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https://doi.org/10.1038/s41598-024-83193-x

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