Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action

Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action

Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An important example is hair cell loss due to exposure to toxic agents including therapeutic drugs such as the...

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Bibliographic Details
Main Authors: Patricia Wu, Francisco Barros-Becker, Roberto Ogelman, Esra D. Camci, Tor H. Linbo, Julian A. Simon, Edwin W. Rubel, David W. Raible
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Neurology
Subjects:
zebrafish
aminoglycoside
ototoxicity
hair cell
lysosome
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1480435/full
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