Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report
Herpes simplex virus type 1 (HSV-1) infections cause typical dermal and mucosal lesions in children and adults. Also complications to the peripheral and central nervous system, pneumonia or hepatitis are well known. However, dissemination to viscera in adults is rare and predominantly observed in im...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2012/359360 |
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| author | Michael Glas Sigrun Smola Thorsten Pfuhl Juliane Pokorny Rainer M. Bohle Arno Bücker Jörn Kamradt Thomas Volk |
| author_facet | Michael Glas Sigrun Smola Thorsten Pfuhl Juliane Pokorny Rainer M. Bohle Arno Bücker Jörn Kamradt Thomas Volk |
| author_sort | Michael Glas |
| collection | DOAJ |
| description | Herpes simplex virus type 1 (HSV-1) infections cause typical dermal and mucosal lesions in children and adults. Also complications to the peripheral and central nervous system, pneumonia or hepatitis are well known. However, dissemination to viscera in adults is rare and predominantly observed in immunocompromised patients. Here we describe the case of a 70-year-old male admitted with macrohematuria and signs of acute infection and finally deceasing in a septic shock with multi organ failure 17 days after admission to intensive care unit. No bacterial or fungal infection could be detected during his stay, but only two days before death the patient showed signs of rectal, orolabial and genital herpes infection. The presence of HSV-1 was detected in swabs taken from the lesions, oropharyngeal fluid as well as in plasma. Post-mortem polymerase chain reaction analyses confirmed a disseminated infection with HSV-1 involving various organs and tissues but excluding the central nervous system. Autopsy revealed a predominantly retroperitoneal diffuse large B-cell lymphoma as the suspected origin of immunosuppression underlying herpes simplex dissemination. |
| format | Article |
| id | doaj-art-b751f95ed3be443cbb57039c93453e7e |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-b751f95ed3be443cbb57039c93453e7e2025-02-03T07:26:04ZengWileyCase Reports in Critical Care2090-64202090-64392012-01-01201210.1155/2012/359360359360Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case ReportMichael Glas0Sigrun Smola1Thorsten Pfuhl2Juliane Pokorny3Rainer M. Bohle4Arno Bücker5Jörn Kamradt6Thomas Volk7Department of Anesthesiology, Intensive Care and Pain Therapy, Saarland University Hospital, Kirrberger Straße, D-66421 Homburg, GermanyInstitute of Virology, Saarland University Hospital, D-66421 Homburg, GermanyInstitute of Virology, Saarland University Hospital, D-66421 Homburg, GermanyInstitute of Pathology, Saarland University Hospital, D-66421 Homburg, GermanyInstitute of Pathology, Saarland University Hospital, D-66421 Homburg, GermanyDepartment of Diagnostic and Interventional Radiology, Saarland University Hospital, D-66421 Homburg, GermanyDepartment of Urology and Pediatric Urology, Saarland University Hospital, D-66421 Homburg, GermanyDepartment of Anesthesiology, Intensive Care and Pain Therapy, Saarland University Hospital, Kirrberger Straße, D-66421 Homburg, GermanyHerpes simplex virus type 1 (HSV-1) infections cause typical dermal and mucosal lesions in children and adults. Also complications to the peripheral and central nervous system, pneumonia or hepatitis are well known. However, dissemination to viscera in adults is rare and predominantly observed in immunocompromised patients. Here we describe the case of a 70-year-old male admitted with macrohematuria and signs of acute infection and finally deceasing in a septic shock with multi organ failure 17 days after admission to intensive care unit. No bacterial or fungal infection could be detected during his stay, but only two days before death the patient showed signs of rectal, orolabial and genital herpes infection. The presence of HSV-1 was detected in swabs taken from the lesions, oropharyngeal fluid as well as in plasma. Post-mortem polymerase chain reaction analyses confirmed a disseminated infection with HSV-1 involving various organs and tissues but excluding the central nervous system. Autopsy revealed a predominantly retroperitoneal diffuse large B-cell lymphoma as the suspected origin of immunosuppression underlying herpes simplex dissemination.http://dx.doi.org/10.1155/2012/359360 |
| spellingShingle | Michael Glas Sigrun Smola Thorsten Pfuhl Juliane Pokorny Rainer M. Bohle Arno Bücker Jörn Kamradt Thomas Volk Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report Case Reports in Critical Care |
| title | Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report |
| title_full | Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report |
| title_fullStr | Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report |
| title_full_unstemmed | Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report |
| title_short | Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report |
| title_sort | fatal multiorgan failure associated with disseminated herpes simplex virus 1 infection a case report |
| url | http://dx.doi.org/10.1155/2012/359360 |
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