Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons
γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontan...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2011/905624 |
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| author | Anne-Emilie Allain Hervé Le Corronc Alain Delpy William Cazenave Pierre Meyrand Pascal Legendre Pascal Branchereau |
| author_facet | Anne-Emilie Allain Hervé Le Corronc Alain Delpy William Cazenave Pierre Meyrand Pascal Legendre Pascal Branchereau |
| author_sort | Anne-Emilie Allain |
| collection | DOAJ |
| description | γ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. In the present paper, we concentrate on brainstem and spinal motoneurons that are largely targeted by GABAergic interneurons, and we bring together data on the switch from excitatory to inhibitory effects of GABA, on the maturation of the GABAergic system and GABAAR subunits. We finally discuss the role of GABA and its GABAAR in immature hypoglossal motoneurons of the spastic (SPA) mouse, a model of human hyperekplexic syndrome. |
| format | Article |
| id | doaj-art-b74bc8d391be4c7d97d9ac95cbd548b0 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-b74bc8d391be4c7d97d9ac95cbd548b02025-02-03T06:08:34ZengWileyNeural Plasticity2090-59041687-54432011-01-01201110.1155/2011/905624905624Maturation of the GABAergic Transmission in Normal and Pathologic MotoneuronsAnne-Emilie Allain0Hervé Le Corronc1Alain Delpy2William Cazenave3Pierre Meyrand4Pascal Legendre5Pascal Branchereau6Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), Université de Bordeaux et CNRS—UMR 5287, avenue des Facultés, 4ème étage Est, 33405 Talence, FranceINSERM U 952, CNRS UMR 7224, Université Pierre et Marie Curie, Bâtiment B, étage 2, boite postale 37, 7 quai Saint Bernard, 75005 Paris, FranceInstitut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), Université de Bordeaux et CNRS—UMR 5287, avenue des Facultés, 4ème étage Est, 33405 Talence, FranceInstitut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), Université de Bordeaux et CNRS—UMR 5287, avenue des Facultés, 4ème étage Est, 33405 Talence, FranceInstitut des Maladies Neurodégénératives (IMN), Université de Bordeaux et CNRS—UMR 5293, avenue des Facultés, 4ème étage Est, 33405 Talence, FranceINSERM U 952, CNRS UMR 7224, Université Pierre et Marie Curie, Bâtiment B, étage 2, boite postale 37, 7 quai Saint Bernard, 75005 Paris, FranceInstitut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), Université de Bordeaux et CNRS—UMR 5287, avenue des Facultés, 4ème étage Est, 33405 Talence, Franceγ-aminobutyric acid (GABA) acting on Cl−-permeable ionotropic type A (GABAA) receptors (GABAAR) is the major inhibitory neurotransmitter in the adult central nervous system of vertebrates. In immature brain structures, GABA exerts depolarizing effects mostly contributing to the expression of spontaneous activities that are instructive for the construction of neural networks but GABA also acts as a potent trophic factor. In the present paper, we concentrate on brainstem and spinal motoneurons that are largely targeted by GABAergic interneurons, and we bring together data on the switch from excitatory to inhibitory effects of GABA, on the maturation of the GABAergic system and GABAAR subunits. We finally discuss the role of GABA and its GABAAR in immature hypoglossal motoneurons of the spastic (SPA) mouse, a model of human hyperekplexic syndrome.http://dx.doi.org/10.1155/2011/905624 |
| spellingShingle | Anne-Emilie Allain Hervé Le Corronc Alain Delpy William Cazenave Pierre Meyrand Pascal Legendre Pascal Branchereau Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons Neural Plasticity |
| title | Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons |
| title_full | Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons |
| title_fullStr | Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons |
| title_full_unstemmed | Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons |
| title_short | Maturation of the GABAergic Transmission in Normal and Pathologic Motoneurons |
| title_sort | maturation of the gabaergic transmission in normal and pathologic motoneurons |
| url | http://dx.doi.org/10.1155/2011/905624 |
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