Serum sPD-1 as a marker of T cell exhaustion in ART-naïve, ART-experienced, and intestinal parasite co-infected HIV-positive adults at the university of Gondar comprehensive specialized hospital, Northwest Ethiopia, 2024

Serum sPD-1 as a marker of T cell exhaustion in ART-naïve, ART-experienced, and intestinal parasite co-infected HIV-positive adults at the university of Gondar comprehensive specialized hospital, Northwest Ethiopia, 2024

Abstract Background Human Immunodeficiency Virus (HIV) remains a significant global health challenge despite advancements in prevention and treatment. It impairs immune function and leads to T-cell exhaustion, driven by sustained expression of the immune checkpoint receptor PD-1, which exists in mem...

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Main Authors: Tadelo Wondmagegn, Wubet Birhan, Eseye Derb, Mulualem Lemma, Hana Yohannes, Degsew Ewunetie Anteneh, Alembante Bazezew, Kebebe Tadesse, Bewuketu Belete Alemu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Infectious Diseases
Subjects:
ART
Ethiopia
HIV
IP
sPD-1
And T cell exhaustion
Online Access:https://doi.org/10.1186/s12879-025-11158-0
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