Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review
Neuronal pentraxin 2 (NP2) plays a significant role in synaptic plasticity, neuronal survival, and excitatory synapse regulation. Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders,...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-12-01
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| Series: | AIMS Neuroscience |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024031 |
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| author | Ubaid Ansari Jimmy Wen Burhaan Syed Dawnica Nadora Romteen Sedighi Denise Nadora Vincent Chen Forshing Lui |
| author_facet | Ubaid Ansari Jimmy Wen Burhaan Syed Dawnica Nadora Romteen Sedighi Denise Nadora Vincent Chen Forshing Lui |
| author_sort | Ubaid Ansari |
| collection | DOAJ |
| description | Neuronal pentraxin 2 (NP2) plays a significant role in synaptic plasticity, neuronal survival, and excitatory synapse regulation. Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, and neuropathies. This literature review extensively analyzes NP2's role in these conditions, thereby highlighting its contributions to synaptic dysfunction, neuroinflammation, and neurotoxic protein aggregation. In Alzheimer's and Parkinson's diseases, NP2 is linked to amyloid-beta aggregation and dopaminergic neuron degeneration, respectively. Additionally, altered NP2 expression is observed in schizophrenia and bipolar disorder, thus suggesting its involvement in synaptic dysfunction and neurotransmitter imbalance. In neuropathic pain and epilepsy, NP2 modulates the synaptic plasticity and inflammatory responses, with altered levels correlating with disease severity. Furthermore, NP2's involvement in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) emphasizes its broad impact on neuronal health. Understanding NP2's multifaceted roles may reveal novel therapeutic targets and improve the clinical outcomes for these neurological disorders. Though the precise role of NP2 remains uncertain, its clinical potential and initial findings justify further investigations into neuronal pentraxins and other related neuroproteins. |
| format | Article |
| id | doaj-art-b71ef6fe675f43198712dbf7cf9ad95f |
| institution | Kabale University |
| issn | 2373-7972 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Neuroscience |
| spelling | doaj-art-b71ef6fe675f43198712dbf7cf9ad95f2025-01-24T01:29:33ZengAIMS PressAIMS Neuroscience2373-79722024-12-0111450551910.3934/Neuroscience.2024031Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature reviewUbaid Ansari0Jimmy Wen1Burhaan Syed2Dawnica Nadora3Romteen Sedighi4Denise Nadora5Vincent Chen6Forshing Lui7California Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USACalifornia Northstate University College of Medicine, USANeuronal pentraxin 2 (NP2) plays a significant role in synaptic plasticity, neuronal survival, and excitatory synapse regulation. Emerging research suggests that NP2 is implicated in the pathogenesis of various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, and neuropathies. This literature review extensively analyzes NP2's role in these conditions, thereby highlighting its contributions to synaptic dysfunction, neuroinflammation, and neurotoxic protein aggregation. In Alzheimer's and Parkinson's diseases, NP2 is linked to amyloid-beta aggregation and dopaminergic neuron degeneration, respectively. Additionally, altered NP2 expression is observed in schizophrenia and bipolar disorder, thus suggesting its involvement in synaptic dysfunction and neurotransmitter imbalance. In neuropathic pain and epilepsy, NP2 modulates the synaptic plasticity and inflammatory responses, with altered levels correlating with disease severity. Furthermore, NP2's involvement in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) emphasizes its broad impact on neuronal health. Understanding NP2's multifaceted roles may reveal novel therapeutic targets and improve the clinical outcomes for these neurological disorders. Though the precise role of NP2 remains uncertain, its clinical potential and initial findings justify further investigations into neuronal pentraxins and other related neuroproteins.https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024031neuronal pentraxin 2synaptic plasticityalzheimer's diseaseparkinson's diseaseschizophrenianeuropathic painepilepsyamyotrophic lateral sclerosis |
| spellingShingle | Ubaid Ansari Jimmy Wen Burhaan Syed Dawnica Nadora Romteen Sedighi Denise Nadora Vincent Chen Forshing Lui Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review AIMS Neuroscience neuronal pentraxin 2 synaptic plasticity alzheimer's disease parkinson's disease schizophrenia neuropathic pain epilepsy amyotrophic lateral sclerosis |
| title | Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review |
| title_full | Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review |
| title_fullStr | Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review |
| title_full_unstemmed | Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review |
| title_short | Analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders: A literature review |
| title_sort | analyzing the potential of neuronal pentraxin 2 as a biomarker in neurological disorders a literature review |
| topic | neuronal pentraxin 2 synaptic plasticity alzheimer's disease parkinson's disease schizophrenia neuropathic pain epilepsy amyotrophic lateral sclerosis |
| url | https://www.aimspress.com/article/doi/10.3934/Neuroscience.2024031 |
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