Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Cardiac dysautonomia is a common nonmotor symptom of Parkinson's disease (PD) associated with loss of sympathetic innervation to the heart and decreased plasma catecholamines. Disease-modifying strategies for PD cardiac neurodegeneration are not available, and biomarkers of target engagement ar...

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Bibliographic Details
Main Authors: Jeanette M Metzger, Helen N Matsoff, Alexandra D Zinnen, Rachel A Fleddermann, Viktoriya Bondarenko, Heather A Simmons, Andres Mejia, Colleen F Moore, Marina E Emborg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226999&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0226999&type=printable

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