The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure

The NE/AAT/CBG axis regulates adipose tissue glucocorticoid exposure

Abstract Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing ‘...

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Main Authors: Luke D. Boyle, Allende Miguelez-Crespo, Mhairi Paul, Elisa Villalobos, Julia N. C. Toews, Lisa Ivatt, Boglarka Nagy, Marisa Magennis, Natalie Z. M. Homer, Ruth Andrew, Victor Viau, Geoffrey L. Hammond, Roland H. Stimson, Brian R. Walker, Mark Nixon
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55693-x
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https://doi.org/10.1038/s41467-024-55693-x

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