The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease
In 1961, David C. Poskanzer and Robert S. Schwab presented a paper, “Studies in the epidemiology of Parkinson’s disease predicting its disappearance as a major clinical entity by 1980.” This paper introduced the hypothesis that Parkinson’s disease was derived from a single aetiology, the influenza v...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2013/167843 |
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| author | Danny Estupinan Sunina Nathoo Michael S. Okun |
| author_facet | Danny Estupinan Sunina Nathoo Michael S. Okun |
| author_sort | Danny Estupinan |
| collection | DOAJ |
| description | In 1961, David C. Poskanzer and Robert S. Schwab presented a paper, “Studies in the epidemiology of Parkinson’s disease predicting its disappearance as a major clinical entity by 1980.” This paper introduced the hypothesis that Parkinson’s disease was derived from a single aetiology, the influenza virus. We review the original Poskanzer and Schwab hypothesis that Parkinson’s disease was based on the association between the 1918-19 influenza epidemic and the later observation of Parkinsonism in some influenza sufferers. We also further explore the prediction that Parkinson’s disease would totally disappear as an entity once original influenza victims were all deceased. Current research has revealed that there are many potential causes and factors important in the occurrence of Parkinson’s disease, postencephalitic Parkinsonism, and encephalitis lethargica. Poskanzer and Schwab presented a novel hypothesis; however, it was proven false by a combination of research and time. |
| format | Article |
| id | doaj-art-b6e1014fb9cc43dbb209e13704a6bd66 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-b6e1014fb9cc43dbb209e13704a6bd662025-02-03T01:29:16ZengWileyParkinson's Disease2090-80832042-00802013-01-01201310.1155/2013/167843167843The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s DiseaseDanny Estupinan0Sunina Nathoo1Michael S. Okun2Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USADepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USADepartment of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USAIn 1961, David C. Poskanzer and Robert S. Schwab presented a paper, “Studies in the epidemiology of Parkinson’s disease predicting its disappearance as a major clinical entity by 1980.” This paper introduced the hypothesis that Parkinson’s disease was derived from a single aetiology, the influenza virus. We review the original Poskanzer and Schwab hypothesis that Parkinson’s disease was based on the association between the 1918-19 influenza epidemic and the later observation of Parkinsonism in some influenza sufferers. We also further explore the prediction that Parkinson’s disease would totally disappear as an entity once original influenza victims were all deceased. Current research has revealed that there are many potential causes and factors important in the occurrence of Parkinson’s disease, postencephalitic Parkinsonism, and encephalitis lethargica. Poskanzer and Schwab presented a novel hypothesis; however, it was proven false by a combination of research and time.http://dx.doi.org/10.1155/2013/167843 |
| spellingShingle | Danny Estupinan Sunina Nathoo Michael S. Okun The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease Parkinson's Disease |
| title | The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease |
| title_full | The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease |
| title_fullStr | The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease |
| title_full_unstemmed | The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease |
| title_short | The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease |
| title_sort | demise of poskanzer and schwab s influenza theory on the pathogenesis of parkinson s disease |
| url | http://dx.doi.org/10.1155/2013/167843 |
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