From unipotency to pluripotency: deciphering protein networks and signaling pathways in the generation of embryonic stem-like cells from murine spermatogonial stem cells

From unipotency to pluripotency: deciphering protein networks and signaling pathways in the generation of embryonic stem-like cells from murine spermatogonial stem cells

Abstract With the significant challenges in using human embryonic stem cells (ESCs) for research and clinical applications, there is a growing impetus to seek alternative pluripotent cell sources. Embryonic stem-like (ES-like) cells emerge as a promising avenue in this pursuit. Our research demonstr...

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Bibliographic Details
Main Authors: Nima Ghasemi, Hossein Azizi, Ali Qorbanee, Thomas Skutella
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Genomics
Subjects:
Spermatogonial stem cells
Embryonic stem-like cells
Microarray analysis
PPI network
Signaling pathways
miRNA and lncRNA
Online Access:https://doi.org/10.1186/s12864-025-11612-y
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https://doi.org/10.1186/s12864-025-11612-y

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