Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring

Maternal dietary DHA and EPA supplementation ameliorates adverse cardiac outcomes in THC-exposed rat offspring

Abstract Cannabis use in pregnancy is associated with low birthweight outcomes. Recent preclinical data suggests that maternal Δ9-tetrahydrocannabinol (THC) exposure leads to decreases in birthweight followed by early cardiac deficits in offspring. Currently, no studies have explored an intervention...

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Main Authors: Kendrick Lee, Mohammed H. Sarikahya, Samantha L. Cousineau, Ken K.-C. Yeung, Amica Lucas, Kara Loudon, Thane Tomy, Gregg T. Tomy, David R. C. Natale, Steven R. Laviolette, Daniel B. Hardy
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Cannabis
Maternal
Omega-3 fatty acids
Cardiac
Δ9-tetrahydrocannabinol (THC)
Endocannabinoid system
Online Access:https://doi.org/10.1038/s41598-025-92844-6
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https://doi.org/10.1038/s41598-025-92844-6

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